518346-05-9

Basic information

• Product Name: 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine
• Synonyms: 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine
• CAS NO: 518346-05-9
• Molecular Weight: 568.569
• Mol File: 518346-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine(518346-05-9)
• EPA Substance Registry System: 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine(518346-05-9)

Safety Data

• Hazardous Substances Data: 518346-05-9(Hazardous Substances Data)

Upstream product

• 497165-57-8 4-[4,5-dibromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-2,3,5,6-tetrafluoro-pyridine 
• 518336-37-3 2,3,5,6-tetrafluoro-4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyridine 
• 101226-33-9 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole 
• 700-16-3 Pentafluoropyridine 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 497165-58-9 4-[4-Bromo-5-pyridin-4-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-2,3,5,6-tetrafluoro-pyridine 

Downstream Products

• 518348-19-1 2,3,5,6-Tetrafluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-pyridine 

Relevant articles and documents

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

2,6-Diamino-3,5-difluoropyridinyl substituted pyridinylimidazoles, -pyrroles, -oxazoles, -thiazoles and -triazoles have been identified as novel p38alpha inhibitors. Pyridinylimidazole 11 potently inhibited LPS-induced TNFalpha in mice, showed good efficacy in the established rat adjuvant (ED(50): 10 mg/kg po b.i.d.) and collagen induced arthritis (ED(50): 5 mg/kg po b.i.d.) with disease modifying properties based on histological analysis of the joints.