519-57-3

Basic information

• Product Name: SULOCHRIN
• Synonyms: 2-(2,6-Dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoic acid methyl ester;2,4',6-Trihydroxy-4-methyl-2'-(methoxycarbonyl)-6'-methoxybenzophenone
• CAS NO: 519-57-3
• Molecular Formula: C₁₇H₁₆O₇
• Molecular Weight: 332.31
• Product Categories: Antibiotics N-SReceptor Tyrosine Kinase Biology;Receptor Tyrosine Kinase Inhibitors;Vascular Endothelial Growth Factor Receptor (VEGFR);Antibiotics;Antibiotics A to;Antibiotic
• Mol File: 519-57-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 242-248 °C (decomp)
• Boiling Point: 576.3°Cat760mmHg
• Flash Point: 212.6°C
• Appearance: /solid
• Density: 1.378g/cm³
• Vapor Pressure: 6.96E-14mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• Solubility: DMF: soluble
• PKA: 6.55±0.25(Predicted)
• CAS DataBase Reference: SULOCHRIN(CAS DataBase Reference)
• NIST Chemistry Reference: SULOCHRIN(519-57-3)
• EPA Substance Registry System: SULOCHRIN(519-57-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 519-57-3(Hazardous Substances Data)

Usage

Description

Sulochrin is a fungal metabolite derived from various species of Aspergillus and Penicillium. It exhibits anti-angiogenic properties by inhibiting VEGF, which leads to the suppression of capillary-like tube formation in human umbilical vein endothelial cells. Additionally, sulochrin serves as an inhibitor of eosinophil activation, degranulation, and chemotaxis.

Uses

Used in Pharmaceutical Industry:
Sulochrin is used as an anti-angiogenic agent for its ability to inhibit VEGF, thereby preventing the formation of new blood vessels that are essential for tumor growth and metastasis.
Used in Immunology and Allergy Treatment:
Sulochrin is used as an inhibitor of eosinophil activation, degranulation, and chemotaxis, making it a potential therapeutic agent for conditions involving eosinophil-mediated inflammation, such as asthma and other allergic diseases.
Used in Cancer Treatment:
Sulochrin is used as a potential therapeutic agent for cancer treatment, specifically for its ability to inhibit angiogenesis, a process that is crucial for tumor growth and metastasis. By targeting VEGF, sulochrin can limit the formation of new blood vessels that supply nutrients and oxygen to the tumor, thereby inhibiting its growth and spread.

InChI:InChI=1/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3

Upstream product

• 247086-79-9 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzoic acid 
• 178749-80-9 2,6-bis-benzyloxy-4-methyl-benzoic acid 5-benzyloxy-2-bromo-3-methoxy-benzyl ester 
• 247086-81-3 (4-benzyloxy-2-hydroxymethyl-6-methoxy-phenyl)-(2,6-bis-benzyloxy-4-methyl-phenyl)-methanone 
• 178749-81-0 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzaldehyde 
• 23565-79-9 2,6-bis-benzyloxy-4-methyl-benzoic acid 
• 97227-86-6 (5-benzyloxy-2-bromo-3-methoxy-phenyl)-methanol 
• 23565-78-8 methyl 2,6-bis(benzyloxy)-4-methylbenzoate 
• 50637-26-8 methyl 3-(benzyloxy)-5-methoxybenzoate 
• 16846-10-9 methyl 2,6-dihydroxy-4-methylbenzoate 
• 50637-28-0 (3-(benzyloxy)-5-methoxyphenyl)methanol 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 178749-82-1 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzoic acid methyl ester 

Downstream Products

• 85003-85-6 methyl 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate 
• 480-67-1 2,6-dihydroxy-4-methyl-benzoic acid 
• 19520-74-2 3-hydroxy-5-methoxy-benzoic acid methyl ester 
• 89367-84-0 sulochrin triacetate 
• 98973-45-6 1,6-Dihydroxy-3-methylxanthon-8-carbonsaeure 
• 57459-07-1 dimethylsulochrin 

Relevant articles and documents

Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester