52147-07-6

Basic information

• Product Name: ethyl 3-(benzyl(isopropyl)amino)-3-oxopropanoate
• Synonyms: ethyl 3-(benzyl(isopropyl)amino)-3-oxopropanoate
• CAS NO: 52147-07-6
• Molecular Weight: 263.337
• Mol File: 52147-07-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-(benzyl(isopropyl)amino)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(benzyl(isopropyl)amino)-3-oxopropanoate(52147-07-6)
• EPA Substance Registry System: ethyl 3-(benzyl(isopropyl)amino)-3-oxopropanoate(52147-07-6)

Safety Data

• Hazardous Substances Data: 52147-07-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1071-46-1 hydrogen ethyl malonate 
• 102-97-6 Benzyl-isopropyl-amin 
• 105-53-3 diethyl malonate 

Relevant articles and documents

Improved Buchner reaction selectivity in the copper-catalyzed reactions of ethyl 3-arylmethylamino-2-diazo-3-oxopropanoates

Ethyl 3-alkyl(arylmethyl)amino-2-diazo-3-oxopropanoates (diazo amidoacetates) generate generally both cyclohepta[c]pyrrolones (Buchner products) and β-lactams (1,4-insertion products), and show obvious N-substituent-controlled chemoselectivity between the intramolecular Buchner reaction and aliphatic 1,4-C-H insertion under the catalysis of copper salts. The less steric N-alkyl substituents in the amide moiety generally favor the aliphatic 1,4-C-H insertion, while the more steric N-alkyl substituents generally favor the Buchner reaction. Compared with rhodium and ruthenium-catalyzed conditions, the current copper-catalyzed conditions improved the Buchner reaction selectivity of ethyl 3-alkyl(arylmethyl)amino-2-diazo-3-oxopropanoates.