52193-85-8

Basic information

• Product Name: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL
• Synonyms: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL;R(+)-1-(2-NAPHTHYL)ETHANOL;(r)-(+)-α-methyl-2-naphthalenemethanol;(R)-(+)-2-(1-Hydroxyethyl)naphthalene;(1R)-1-(2-Naphthyl)ethanol;(R)-α-Methylnaphthalene-2-methanol;(αR)-α-Methylnaphthalene-2-methanol;(R)-(+)-alpha-Methyl-2-naphthalenemethanol (R)-(+)-2-(1-Hydroxyethyl)naphthalene
• CAS NO: 52193-85-8
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.22
• Product Categories: Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry
• Mol File: 52193-85-8.mol
• Article Data: 332

Chemical Properties

• Melting Point: 68-70 °C(lit.)
• Boiling Point: 316°Cat760mmHg
• Flash Point: 145.4°C
• Appearance: /
• Density: 1.113
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 40 ° (C=1, MeOH)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol,Toluene
• BRN: 3195952
• CAS DataBase Reference: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(52193-85-8)
• EPA Substance Registry System: (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL(52193-85-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 52193-85-8(Hazardous Substances Data)

Usage

Description

(R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL, also known as (R)-(+)-1-(2-Naphthyl)ethanol, is an organic compound with a specific chiral center. It is characterized by its unique molecular structure, which includes a naphthalene ring and an ethanol group. (R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL is optically active and plays a crucial role in the synthesis of various other chemicals.

Uses

Used in Chemical Synthesis:
(R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL is used as a key intermediate in the synthesis of (S)-2-chloro-1-phenylethanol. This is achieved by reacting it with 2-chloroacetophenone in the presence of a chiral bidentate titanium Lewis acid catalyst. The resulting product, (S)-2-chloro-1-phenylethanol, has potential applications in the pharmaceutical industry.
Used in Research and Development:
(R)-(+)-ALPHA-METHYL-2-NAPHTHALENEMETHANOL is a valuable research chemical. It is utilized in the development and optimization of chiral catalysts and synthetic methods, which are essential for producing enantiomerically pure compounds. These pure compounds are often required for various applications, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C12H12O/c1-9(13)11-7-6-10-4-2-3-5-12(10)8-11/h2-9,13H,1H3/t9-/m1/s1

Upstream product

• 108-05-4 vinyl acetate 
• 7228-47-9 2-(2-naphthyl)ethanol 
• 32860-25-6 (R)-1-(2-naphtyl)ethyl acetate 
• 827-54-3 2-naphthylethylene 
• 18006-13-8 methyltriisopropoxytitanium(IV) 
• 66-99-9 β-naphthaldehyde 
• 97-72-3 2-Methylpropionic anhydride 
• 123-62-6 propionic acid anhydride 
• 20176-11-8 2-naphthalene carboxylic anhydride 
• 106-31-0 butanoic acid anhydride 
• 64985-86-0 1-naphthoic anhydride 
• 85880-67-7 1-(2-naphthyl)ethyl acetate 
• 452295-53-3 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecanoic acid 1-naphthalen-2-yl-ethyl ester 
• 71-36-3 butan-1-ol 

Downstream Products

• 175288-44-5 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-naphthalen-2-yl-ethyl ester 
• 1159252-69-3 (3S)-(R)-1-(naphthalen-2-yl)ethyl 1-methyl-2-oxo-3-phenylpyrrolidine-3-carboxylate 
• 1159252-70-6 (3R)-(R)-1-(naphthalen-2-yl)ethyl 1-methyl-2-oxo-3-phenylpyrrolidine-3-carboxylate 
• 130814-87-8 (S)-6-Methyl-5-((R)-1-naphthalen-2-yl-ethoxy)-2-phenyl-5,8-dihydro-[1,2,4]triazolo[1,2-a]pyridazine-1,3-dione 
• 130814-88-9 (S)-4-Methyl-3-((R)-1-naphthalen-2-yl-ethoxy)-cyclohex-4-ene-1,1,2,2-tetracarbonitrile 
• 175288-51-4 (R)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-52-5 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-53-6 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-methyl-1-naphthalen-2-yl-propyl ester 
• 175288-54-7 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester 
• 3082-62-0 (1S)-1-(2-naphthyl)ethylamine 
• 93-08-3 methyl 2-naphthyl ketone 
• 7228-47-9 2-(2-naphthyl)ethanol 

Relevant articles and documents

Ruthenium-catalyzed stereospecific benzylic alkylation of optically active benzyl esters with malonate nucleophiles

The transition metal-catalyzed stereospecific benzylic alkylation of optically active benzyl esters with active methylene compounds remains extremely rare. Herein, we describe the study for the ruthenium-catalyzed benzylic alkylation of chiral benzyl este

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.