521970-04-7Relevant articles and documents
Synthesis and quantitative structure-activity relationships of N-(1- benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective σ1 receptor ligands
Huang, Yunsheng,Hammond, Philip S.,Whirrett, Brian R.,Kuhner, Ross J.,Wu, Li,Childers, Steven R.,Mach, Robert H.
, p. 2361 - 2370 (2007/10/03)
A series of N-(1-benzylpiperidin-4-yl)phenylacetamide derivatives was synthesized and evaluated for affinity at σ1 and σ2 receptors. Most of these compounds showed a high affinity for σ1 receptors and a low to moderate aff
Enzymatic Preparation of Optically Active Cyanohydrin Acetates
Almsick, Andreas van,Buddrus, Joachim,Hoenicke-Schmidt, Petra,Laumen, Kurt,Schneider, Manfred P.
, p. 1391 - 1393 (2007/10/02)
A series of cyanohydrin acetates (1)-(47) of widely varying structures, potential chiral building blocks for numerous synthetic applications, has been prepared in good chemical and often high optical yields by enzymatic hydrolysis of their racemic acetates in the presence of an ester hydrolase from Pseudomonas sp.