52273-55-9Relevant articles and documents
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
Romussi, Alessia,Cappa, Anna,Vianello, Paola,Brambillasca, Silvia,Cera, Maria Rosaria,Dal Zuffo, Roberto,Fagà, Giovanni,Fattori, Raimondo,Moretti, Loris,Trifirò, Paolo,Villa, Manuela,Vultaggio, Stefania,Cecatiello, Valentina,Pasqualato, Sebastiano,Dondio, Giulio,So, Chi Wai Eric,Minucci, Saverio,Sartori, Luca,Varasi, Mario,Mercurio, Ciro
supporting information, p. 754 - 759 (2020/03/04)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent enzyme that acts as a transcription corepressor or coactivator by regulating the methylation status of histone H3 lysines K4 and K9, respectively. KDM1A represents an attractive target for c
Copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-containing 1,6-enynes
He, Cheng-Yu,Xie, Li-Bo,Ding, Rui,Tian, Ping,Lin, Guo-Qiang
supporting information, p. 1682 - 1688 (2019/01/04)
The first copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-containing 1,6-enynes has been accomplished through a tandem process: regioselective silylcupration of terminal unactivated alkynes and subsequently enantioselective conjugate addition to cyclohexadienones. This reaction proceeded smoothly to afford the cis-hydrobenzofuran and cis-hydroindole frameworks bearing two consecutive chiral carbon centers in high to excellent yields and moderate enantioselectivities. Additionally, the cyclization products could be readily subjected to several transformations for elaborating synthetic utilities.
Diphenyl sulfate derivatives, preparation method of thereof and fluorophore sensor comprising thereof
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Paragraph 0236-0239, (2017/06/02)
The present invention relates to a diphenyl sulfate derivative, a method for preparing the same, and a fluorescence bio-sensor comprising the same. The diphenyl sulfate derivative having a novel structure according to the present invention traces cells and carries out immuno-fluorescence staining of the mitochondria of the cells satisfactorily. Thus, the diphenyl sulfate sulfate is useful in the glioma-related field and the research field including virus and DNA transfection, and can be used advisably as fluorescence bio-sensor for diagnosing diseases, such as glioma, sarcoma or leukemia.