52463-83-9 Usage
Description
Pinazepam is a benzodiazepine derivative that exhibits anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It is considered less toxic than Diazepam and is classified as a controlled substance with depressant effects.
Uses
Used in Pharmaceutical Industry:
Pinazepam is used as an anxiolytic agent for the treatment of anxiety disorders. Its anxiolytic properties help alleviate symptoms of anxiety and stress, providing relief to patients suffering from such conditions.
Used in Neurology:
In the field of neurology, pinazepam is utilized as an anticonvulsant medication to control and prevent seizures. Its effectiveness in managing seizure activity makes it a valuable tool in the treatment of various seizure disorders.
Used in Sleep Aid Applications:
Due to its sedative properties, pinazepam is used as a sleep aid for individuals experiencing insomnia or other sleep-related issues. It helps promote relaxation and drowsiness, allowing for a more restful and uninterrupted sleep.
Used in Muscle Relaxation:
Pinazepam is also used as a muscle relaxant to alleviate muscle spasms, pain, and stiffness. Its ability to relax skeletal muscles makes it a useful treatment option for conditions characterized by muscle tension and discomfort.
Used in Anesthesia:
In the context of anesthesia, pinazepam is employed as an adjunct to provide sedation and reduce anxiety during medical procedures. Its sedative and anxiolytic effects help patients remain calm and relaxed throughout the process.
Overall, pinazepam's diverse range of applications in the medical field highlights its versatility and effectiveness in addressing various health concerns related to anxiety, seizures, sleep, muscle relaxation, and anesthesia.
Originator
Domar ,Zambeletti, Italy,1975
Manufacturing Process
46.3 g (0.2 mol) of 2-amino-5-chlorobenzophenone were dissolved in 100 ml (1.28 mols) of propargyl bromide and the mixture refluxed for 4 hours. Thereafter, the whole was evaporated to dryness and the residue recrystallized from methanol to give 32.4 g (60.2%) of the desired 2-propargylamino-5chlorobenzophenone; melting point 92°C to 93°C.2.7 g (0.01 mol) of the 2-propargylamino-5-chlorobenzophenone obtained as above and 2.23 g (0.01 mol) of phthalimidoacetyl chloride were added to 30 ml of chloroform and the whole was refluxed overnight. Thereafter, the reaction mixture was evaporated to dryness and the residue recrystallized from methanol to give 2.66 g (58.3%) of the desired 2-(Npropargyl)phthalimidoacetamide-5-chlorobenzophenone. Melting point: 176°C.A suspension of 22.8 g (0.05 mol) of 2-(N-propargyl)-phthalimidoacetamido5-chlorobenzophenone in 250 ml ethanol containing 7.5 g hydrazine hydrate (0.15 mol) was heated under reflux for 2 hours, at the end of which time the reaction mixture was set aside overnight at ambient (25°C) temperature. Thereafter, the crystalline phthalyl hydrazide which had precipitated out was removed by filtration and washed with 3 x 50 ml aliquots of chloroform. The filtrate and washings were diluted with water and exhaustively extracted with chloroform. The chloroform extract was then evaporated and the residue washed with 100 ml hexane to promote crystallization. The crude 7-chloro-1propargyl-3H-1,4-benzodiazepine-2(1H)-one was recrystallized from a methanol-water mixture to give 10.5 g (71.4%) of the pure product. Melting point: 140°C to 142°C.
Therapeutic Function
Antidepressant
Check Digit Verification of cas no
The CAS Registry Mumber 52463-83-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,6 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 52463-83:
(7*5)+(6*2)+(5*4)+(4*6)+(3*3)+(2*8)+(1*3)=119
119 % 10 = 9
So 52463-83-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H13ClN2O/c1-2-10-21-16-9-8-14(19)11-15(16)18(20-12-17(21)22)13-6-4-3-5-7-13/h1,3-9,11H,10,12H2
52463-83-9Relevant articles and documents
7-Chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazepine-2-one, and a pharmaceutical composition thereof
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, (2008/06/13)
The invention relates to 1-propargyl-5-(halo) phenyl-1,4-benzodiazepines, and particularly to 7-chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazepine-2-one endowed with psycho-sedative, low myorelaxant, high anxiolytic, anticonvulsant and hypnotic properties.
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