526222-45-7Relevant articles and documents
The concept of internal solubilization in peptide synthesis: ethylene glycol-based protecting groups
Kocsis, László,Bruckdorfer, Thomas,Orosz, Gy?rgy
body text, p. 7015 - 7017 (2009/04/07)
A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis. Ether and ester type protected amino acids are prepared. The acid stability of the new protecting group showed complete Fmoc/t-Bu compatibility. The new derivatives are tested in solid phase peptide synthesis, with a 'difficult' sequence to examine the disruption of peptide aggregation.