52707-50-3

Basic information

• Product Name: Benzaldehyde, 3-methyl-, oxime, (E)- (9CI)
• Synonyms: Benzaldehyde, 3-methyl-, oxime, (E)- (9CI)
• CAS NO: 52707-50-3
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16316
• Product Categories: OXIME
• Mol File: 52707-50-3.mol
• Article Data: 59

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzaldehyde, 3-methyl-, oxime, (E)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-methyl-, oxime, (E)- (9CI)(52707-50-3)
• EPA Substance Registry System: Benzaldehyde, 3-methyl-, oxime, (E)- (9CI)(52707-50-3)

Safety Data

• Hazardous Substances Data: 52707-50-3(Hazardous Substances Data)

Upstream product

• 620-23-5 m-tolyl aldehyde 
• 109423-08-7 1,3,5-tris(m-tolyl)perhydro-1,3,5-triazine 
• 108-44-1 1-amino-3-methylbenzene 
• 100-81-2 3-methyl-benzenemethanamine 
• 104-87-0 4-methyl-benzaldehyde 
• 591-17-3 meta-bromotoluene 
• 68-12-2 N,N-dimethyl-formamide 
• 587-03-1 3-methylbenzyl alcohol 
• 15728-26-4 2-(3-methylbenzylidene)malononitrile 

Downstream Products

• 26166-63-2 1-dinitromethyl-3-methyl-benzene 
• 100-81-2 3-methyl-benzenemethanamine 
• 26995-44-8 3-methyl-benzaldehyde (E)-O-(1,1-dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yl)-oxime 
• 90732-97-1 Phenyl-(5-m-tolyl-[1,2,4]oxadiazol-3-yl)-methanone 
• 134589-64-3 Bis-[1-m-tolyl-meth-(Z)-ylidene]-diazene N,N'-dioxide 
• 620-23-5 m-tolyl aldehyde 
• 620-22-4 3-Methylbenzonitrile 
• 1414939-09-5 (E)-5-methoxy-4-styryl-2-(m-tolyl)oxazole 
• 1422283-20-2 C₁₃H₁₅NO₂ 
• 1422283-29-1 C₁₃H₁₃NO₃ 
• 1613642-64-0 C₂₆H₂₀N₂O₂ 
• 1613642-65-1 C₂₈H₁₈N₄O₂ 
• 1613643-09-6 C₂₈H₂₆N₄O₂ 
• 1613643-10-9 C₃₀H₃₀N₈O₂ 

Relevant articles and documents

UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION

Compounds of formulae (I) and (II), compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells invivo, in vitro, or ex vivo.

Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors

α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.

On the mixed oxides-supported niobium catalyst towards benzylamine oxidation

A series of mixed oxides-supported niobium-based catalysts has been synthesized and applied towards oxidation reactions of benzylamine derivatives. Under the optimized reaction conditions, the selectivity to oxime enhanced, leading to the main product with up to 72 %. Moreover, even α-substituted benzylamines were well tolerated and led to oximes in good isolated yields. It is important to mention; four equivalents of the harmless and inexpensive hydrogen peroxide were employed as oxidizing agent. Mechanism hypothesis suggested that the reaction proceed to selective benzylamine oxidation into nitroso intermediate, following by formation of the corresponding oxime tautomer mediated by an unstable water produced by NbOx supported catalyst. This consists the first mixed oxides-supported niobium-based catalyst for selective oxidation of benzylamines to oximes.