53-33-8 Usage
Description
Paramethasone is a fluorinated glucocorticoid, a class of corticosteroids that exhibit potent anti-inflammatory and immunosuppressant properties. It is synthesized to mimic the effects of naturally occurring cortisol, a hormone produced by the adrenal glands. Paramethasone is used in various medical applications due to its ability to reduce inflammation, suppress the immune system, and alleviate symptoms of various conditions.
Uses
Used in Pharmaceutical Industry:
Paramethasone is used as an anti-inflammatory agent for reducing inflammation and relieving pain in conditions such as arthritis, bursitis, and tendonitis. Its potent anti-inflammatory effects make it a valuable treatment option for a wide range of inflammatory disorders.
Paramethasone is used as an immunosuppressant for suppressing the immune system in conditions where the immune response is overactive or causing harm to the body, such as autoimmune diseases, organ transplant rejection, and severe allergic reactions.
Used in Dermatology:
In the field of dermatology, Paramethasone is used as a topical treatment for various skin conditions, including eczema, psoriasis, and dermatitis. Its anti-inflammatory and immunosuppressant properties help to reduce redness, itching, and swelling associated with these conditions.
Used in Ophthalmology:
Paramethasone is used as an ocular anti-inflammatory agent in the treatment of eye conditions such as uveitis, iritis, and allergic conjunctivitis. Its ability to reduce inflammation and suppress the immune response in the eye makes it an effective treatment option for these conditions.
Used in Respiratory Medicine:
In respiratory medicine, Paramethasone is used as an inhaled corticosteroid for the management of asthma and chronic obstructive pulmonary disease (COPD). Its anti-inflammatory properties help to reduce inflammation in the airways, improving lung function and reducing the frequency of asthma attacks.
Used in Allergy Treatment:
Paramethasone is used as an anti-allergic agent for the treatment of severe allergic reactions, such as anaphylaxis. Its immunosuppressant properties help to dampen the immune response, reducing the severity of the allergic reaction and providing relief from symptoms.
Therapeutic Function
Glucocorticoid
Check Digit Verification of cas no
The CAS Registry Mumber 53-33-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53-33:
(4*5)+(3*3)+(2*3)+(1*3)=38
38 % 10 = 8
So 53-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
53-33-8Relevant articles and documents
Preparation method of palamethasone acetate and palamethasone
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Paragraph 0035; 0061-0064, (2022/03/27)
The invention provides a palamethasone acetate and a preparation method of palamethasone, 16-methyl hydroxyl epoxy progesterone is used as an initial raw material, fluorination, bromination, debromination, iodination and replacement reaction are sequentially performed to obtain the palamethasone acetate, and then the palamethasone acetate is hydrolyzed to obtain the palamethasone. The preparation process route provided by the invention has fewer reaction steps, the quality and yield of the product have obvious competitiveness, dangerous chemical processes are not involved, the method is green and clean, and the atom economy is improved; the preparation process has a wide industrial application prospect.
Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
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, (2008/06/13)
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a gradual and relatively constant release of the pharmaceuticals over at least a 12-hour period.
Amine containing ester prodrugs of corticosteroids
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, (2008/06/13)
Novel solution stable ester prodrugs of corticosteroids of the formula STR1
