53195-68-9

Basic information

• Product Name: N^α-BOC-N^ε-Z-Lys-Pro-OMe
• Synonyms: N^α-BOC-N^ε-Z-Lys-Pro-OMe
• CAS NO: 53195-68-9
• Molecular Weight: 491.585
• Mol File: 53195-68-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N^α-BOC-N^ε-Z-Lys-Pro-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-BOC-N^ε-Z-Lys-Pro-OMe(53195-68-9)
• EPA Substance Registry System: N^α-BOC-N^ε-Z-Lys-Pro-OMe(53195-68-9)

Safety Data

• Hazardous Substances Data: 53195-68-9(Hazardous Substances Data)

Upstream product

• 2389-45-9 Boc-Lys(Z)-OH 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 2389-46-0 N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester 
• 84890-96-0 C₂₄H₃₆N₂O₈ 
• 42460-90-2 (S)-Pyrrolidine-2-carboxylic acid methyl ester; compound with trifluoro-acetic acid 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 56-87-1 L-lysine 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 543-27-1 isobutyl chloroformate 
• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 

Downstream Products

• 53734-02-4 H-Lys(Z)-Pro-OMe 
• 85574-67-0 H-Lys(Z)-Pro-OMe*HCl 
• 108456-08-2 H-Lys(Z)-Pro-OMe*TFA 
• 1220668-97-2 Boc-Ile-Lys(Cbz)-Pro-OMe 
• 126733-91-3 Boc-Arg(NO₂)-Pro-Lys(Z)-Pro-Gln-OCH₂Ph 
• 78314-59-7 Z₃Arg-Pro-Lys(Z)-Pro-OMe 

Relevant articles and documents

Cyclodipeptide c(Orn-Pro) Conjugate with 4-Ethylpiperic Acid Abrogates Cancer Cell Metastasis through Modulating MDM2

The present work describes the synthesis, characterization, and anticancer properties of c(Lys-Pro), P1; c(Orn-Pro), P2; and conjugates PA-c(Lys-Pro), C1; PA-c(Orn-Pro), C2; EPA-c(Lys-Pro), C3; and EPA-c(Orn-Pro), C4. Among all, conjugate C4 displays pote

Stereoselective Synthesis of β-(5-Arylthiazolyl) α-Amino Acids and Use in Neurotensin Analogues

A series of new unnatural amino acids bearing a β-arylthiazole side chain was synthesized by exploiting a diastereoselective alkylation starting from glycine tert-butyl ester Schiff base with hydroxypinanone as the chiral inducer. This strategy afforded β-arylthiazole alanines in good chemical yields and with 98 % ee. Due to their aromatic properties, these newly generated amino acids were used to prepare neurotensin (NT)[8-13] analogues by serving as replacements for the native Tyr11 residue. Incorporation of the (L)-(+)-(β-phenylthiazol-4-yl)alanine residue at NT[8-13] position 11 improved plasma stability and selectivity towards NTS1, while also preserving native receptor binding affinity and biological activity. New β-arylthiazole alanines were synthesized in good chemical yields and with 98 % ee using a diastereoselective alkylation; these alanine derivatives were then used as Tyr11 replacements in the construction of neurotensin (NT)[8-13] analogues. The new NT analogues showed improved plasma stability and selectivity towards NTS1 thus preserving the hypotensive properties of the native peptide.

NOVEL SMALL MOLECULE DNAK INHIBITORS

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