53213-26-6

Basic information

• Product Name: PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE
• Synonyms: PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE
• CAS NO: 53213-26-6
• Molecular Formula: Br*C₂₆H₂₄P
• Molecular Weight: 447.346521
• Mol File: 53213-26-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 216 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE(53213-26-6)
• EPA Substance Registry System: PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE(53213-26-6)

Safety Data

• Hazardous Substances Data: 53213-26-6(Hazardous Substances Data)

Usage

Description

PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE, also known as an arylphosphonium salt, is a compound that has been studied for its interactions with DNA and its potential cytotoxicity modulation. It possesses unique properties that make it a promising candidate for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE is used as a DNA-interacting agent for modulating cytotoxicity. Its interaction with DNA allows it to potentially influence cellular processes and contribute to the development of new therapeutic strategies.
Used in Antimicrobial Applications:
PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE is used as an antibacterial agent for its potential to combat bacterial infections. PHENETHYLTRIPHENYLPHOSPHONIUM BROMIDE has been studied as a result of the quaternization of triphenylphosphine with benzyl halides, which may contribute to its antimicrobial properties.

InChI:InChI=1/C26H24P/c1-5-13-23(14-6-1)21-22-27(24-15-7-2-8-16-24,25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20H,21-22H2/q+1

Upstream product

• 60-12-8 2-phenylethanol 
• 30537-09-8 (1-phenylethyl)triphenylphosphonium bromide 
• 100-42-5 styrene 
• 603-35-0 triphenylphosphine 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 100-39-0 benzyl bromide 
• 103-63-9 1-phenyl-2-bromoethane 
• 5044-52-0 vinyltriphenylphosphonium bromide 
• 591-51-5 phenyllithium 

Downstream Products

• 259263-42-8 1-methoxy-4-phenethylenetetrahydropyran 
• 1239600-74-8 (E)-1-bromo-2-(3-phenylprop-1-en-1-yl)benzene 
• 798556-17-9 (1E,3Z)-1-p-tolyl-5-phenylpenta-1,3-diene 
• 745814-64-6 3-[2-Phenyl-eth-(E)-ylidene]-piperidine-1-carboxylic acid tert-butyl ester 
• 32895-98-0 2-phenylphenanthro<9,10-b>furan 
• 602313-45-1 4,5-methylenedioxy-2-(2-phenylvinyl)phenol 
• 4489-84-3 3-methyl-1-phenylbut-2-ene 
• 56434-73-2 1-phenyl-3-methylbut-2-ene-4,4,4,3',3',3'-d6 
• 185320-30-3 (4-Chloro-3-chloromethyl-but-2-enyl)-benzene 
• 53213-08-4 triphenyl phosphoranylidene 1-phenyl-ethane 
• 1142-21-8 (Z)-1,4-diphenylbut-2-ene 
• 100-42-5 styrene 

Relevant articles and documents

Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity

Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-c

Enantioselective palladium-catalyzed addition of malonates to 3,3-difluoropropenes

Monofluoroalkenes bearing a malonate unit at the β position can be synthesized by the enantioselective addition of diesters to 3,3-difluoropropenes. The difference in reactivity regarding the geometry and the substituents of the alkene of the 3,3-difluoropropenes, as well as the alkyl groups of the malonates, was studied and limitations were identified. The reaction was also performed with different 3,3-difluoropropenes. Further synthetic transformations of a newly functionalized monofluoroalkene were also accomplished.

ALKENES AS ALKYNE EQUIVALENTS IN RADICAL CASCADES TERMINATED BY FRAGMENTATIONS

Disclosed are methods for rerouting radical cascade cyclizations by using alkenes as alkyne equivalents. The reaction sequence is initiated by a novel 1,2 stannyl shift which achieves chemo- and regioselectivity in the process. The radical “hopping” leads to the formation of the radical center necessary for the sequence of selective cyclizations and fragmentations to follow. In the last step of the cascade, the elimination of a rationally designed radical leaving group via β-C—C bond scission aromatizes the product without the need for external oxidant. The Bu3Sn moiety, which is installed during the reaction sequence, allows further functionalization of the product via facile reactions with electrophiles as well as Stille and Suzuki cross-coupling reactions. This selective radical transformation opens a new approach for the controlled transformation of enynes into extended polycyclic structures of tunable dimensions.