5329-15-7

Basic information

• Product Name: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE
• Synonyms: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE;CHEMBRDG-BB 9063927;N-(4-amino-2-methoxyphenyl)-3-oxobutanamide;2-METHOXY-4-AMINOACETANILIDE;4'-Amino-2'-methoxyacetanilide;4'-Aminoacetoanisizide;N-(2-Methoxy-4-aminophenyl)acetamide;N-(4-azanyl-2-methoxy-phenyl)ethanamide
• CAS NO: 5329-15-7
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.2
• Mol File: 5329-15-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 280.7°Cat760mmHg
• Flash Point: 123.6°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 0.00373mmHg at 25°C
• Refractive Index: 1.607
• PKA: 14.12±0.70(Predicted)
• CAS DataBase Reference: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE(5329-15-7)
• EPA Substance Registry System: N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE(5329-15-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5329-15-7(Hazardous Substances Data)

Usage

Description

N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE, also known as 4-Amino-2-methoxybenzamide, is a chemical compound with the molecular formula C9H11N2O2. It is a derivative of acetanilide and is commonly used in the field of medicinal chemistry for its potential pharmaceutical properties. N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE has been studied for its potential as an anti-inflammatory and analgesic agent due to its structural similarity to other known compounds with these properties. It is also being investigated for its potential in the treatment of various diseases, making it an important chemical in drug discovery and development. Additionally, N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE has been studied for its potential as an intermediate in the synthesis of other organic compounds.

Uses

Used in Pharmaceutical Industry:
N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE is used as a pharmaceutical agent for its potential anti-inflammatory and analgesic properties. Its structural similarity to other compounds with these properties makes it a promising candidate for the development of new medications to treat pain and inflammation.
Used in Drug Discovery and Development:
N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE is used as a chemical in drug discovery and development due to its potential in the treatment of various diseases. Its investigation for these applications contributes to the advancement of new therapeutic options for patients.
Used as an Intermediate in Organic Synthesis:
N-(4-AMINO-2-METHOXYPHENYL)ACETAMIDE is used as an intermediate in the synthesis of other organic compounds. Its role in the production of various chemical entities highlights its utility in the broader field of organic chemistry and the creation of new molecules with potential applications.

InChI:InChI=1/C9H12N2O2/c1-6(12)11-8-4-3-7(10)5-9(8)13-2/h3-5H,10H2,1-2H3,(H,11,12)

Upstream product

• 93-27-6 5-nitro-2-acetylaminoanisole 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 25351-89-7 N-(2-hydroxy-4-nitrophenyl)acetamide 

Downstream Products

• 93532-96-8 4-acetoacetylamino-1-acetylamino-2-methoxy-benzene 
• 102161-15-9 N,N'-bis-(4-acetylamino-3-methoxy-phenyl)-urea 
• 59557-91-4 4-bromo-2-methoxyaniline 
• 83209-82-9 N-<2-methoxy-4-<(methylsulfonyl)amino>phenyl>acetamide 
• 105168-66-9 C₁₁H₁₇N₃O₄S 
• 87223-51-6 C₁₄H₁₈N₄O₆ 
• 105168-67-0 C₉H₁₅N₃O₃S 
• 105168-68-1 C₁₄H₂₁N₅O₇S 
• 86733-81-5 5-(4-amino-3-methoxybenzyl)thiazolidine-2,4-dione 
• 86733-82-6 5-(4-acetamido-3-methoxybenzyl)thiazolidine-2,4-dione 
• 86733-95-1 5-(4-acetamido-3-methoxybenzyl)-2-iminothiazolidin-4-one 
• 106994-15-4 N-(4-amino-5-methoxy-2-nitrophenyl)-N-(2-propenyl)methanesulfonamide 
• 116911-55-8 N-(4-acetamido-5-mthoxy-2-nitrophenyl)methanesulfonamide 
• 116911-56-9 N-(4-acetamido-5-methoxy-2-nitrophenyl)-N-(2-propenyl)methanesulfonamide 

Relevant articles and documents

Discovery of wtRET and V804MRET Inhibitors: From Hit to Lead

Oncogenic activation of RET kinase has been found in several neoplastic diseases, like medullary thyroid carcinoma, multiple endocrine neoplasia, papillary thyroid carcinoma, and non-small-cell lung cancer. Currently approved RET inhibitors were not originally designed to be RET inhibitors, and their potency against RET kinase has not been optimized. Hence, novel compounds able to inhibit both wild-type RET (wtRET) and its mutants (e.g., V804MRET) are needed. Herein we present the development and the preliminary evaluation of a new sub-micromolar wtRET/V804MRET inhibitor, N-(2-fluoro-5-trifluoromethylphenyl)-N′-{4′-[(2′′-benzamido)pyridin-4′′-ylamino]phenyl}urea (69), endowed with a 4-anilinopyridine structure, starting from our previously identified 4-anilinopyrimidine hit compound. Profiling against a panel of kinases indicated 69 as a multi cKIT/wtRET/V804MRET inhibitor.

Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921

An improved process for the synthesis of bulk quantities of the clinical amsacrine analog CI-921 is reported. Described also are detailed analytical and spectroscopic data for this agent.

Quinone Imine Route to Benzimidazol-2-ylcarbamates. Part 1. Synthesis of Open-chain and Cyclic 5-Acylamino Derivatives.

The synthesis of the N',N''-bismethoxycarbonyl-N-(4-acylaminophenyl)guanidines (4) and (7) is described.Oxidation of these with LTA has led to the benzimidazol-2-ylcarbamates. (8), (9) and (10) through a regiospecific cyclisation of quinone imine intermediates.If the acylamino group is part of a ring, the yield of benzimidazoles (15) increases with the size of the lactam ring.The direction of ring closure may be controlled by electronic and steric factors.