5330-43-8

Basic information

• Product Name: N-[(E)-(2,4-dichlorophenyl)methylidene]aniline
• Synonyms: Aniline, N- (2,4-dichlorobenzylidene)-; benzenamine, N-[(1E)-(2,4-dichlorophenyl)methylene]-; N-[(E)-(2,4-Dichlorophenyl)methylene]aniline
• CAS NO: 5330-43-8
• Molecular Formula: C₁₃H₉Cl₂N
• Molecular Weight: 250.1233
• Mol File: 5330-43-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 358.4°C at 760 mmHg
• Flash Point: 170.6°C
• Density: 1.2g/cm³
• Vapor Pressure: 5.26E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: N-[(E)-(2,4-dichlorophenyl)methylidene]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-(2,4-dichlorophenyl)methylidene]aniline(5330-43-8)
• EPA Substance Registry System: N-[(E)-(2,4-dichlorophenyl)methylidene]aniline(5330-43-8)

Safety Data

• Hazardous Substances Data: 5330-43-8(Hazardous Substances Data)

Usage

Description

N-[(E)-(2,4-dichlorophenyl)methylidene]aniline is a chemical compound with the formula C13H10Cl2N. It is an aniline derivative that contains a substituted benzene ring with two chlorine atoms and an attached methylidene group.

Uses

Used in Organic Synthesis:
N-[(E)-(2,4-dichlorophenyl)methylidene]aniline is used as a building block in organic synthesis for the creation of various complex organic compounds.
Used in Pharmaceutical Production:
N-[(E)-(2,4-dichlorophenyl)methylidene]aniline is used as a precursor in the production of various pharmaceuticals, contributing to the development of new drugs.
Used in Agrochemical Production:
N-[(E)-(2,4-dichlorophenyl)methylidene]aniline is also used as a precursor in the production of agrochemicals, aiding in the development of pesticides and other agricultural chemicals.
Used in Dye and Pigment Manufacturing:
N-[(E)-(2,4-dichlorophenyl)methylidene]aniline is utilized in the manufacturing of dyes and pigments, providing colorants for various industries.
Health Hazards:
N-[(E)-(2,4-dichlorophenyl)methylidene]aniline has potential health hazards and should be handled with care. Exposure to the compound can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 62-53-3 aniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 98-95-3 nitrobenzene 

Downstream Products

• 14225-79-7 2-(2,4-dichlorophenyl)-1H-benzimidazole 
• 1185309-41-4 (S)-5-((R)-(2,4-dichlorophenyl)(phenylamino)methyl)furan-2(5H)-one 
• 1231728-68-9 N-[1-(2,4-dichlorophenyl)-3,3,3,2,2-pentafluoropropyl]aniline 
• 139954-42-0 6-(2,4-Dichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 78444-56-1 3,5-dichloro-4'-fluoro<1,1'-biphenyl>-2-carboxaldehyde 
• 131298-37-8 2-(cyclohexylmethyl)-4,6-dichlorobenzyl alcohol 
• 131298-38-9 (4-Chloro-2,6-bis-cyclohexylmethyl-phenyl)-methanol 
• 78444-64-1 3,5-Dichloro-3'-fluoro-biphenyl-2-carbaldehyde 
• 139954-47-5 6-(2,4-Dichloro-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 122451-93-8 2-(n-butyl)-4,6-dichlorobenzaldehyde 

Relevant articles and documents

Nanomagnetic catalysis (Fe3O4@S–TiO2): a novel magnetically nano catalyst for the synthesis of new highly substituted tetrahydropyridine derivatives under solvent-free conditions

A novel nanomagnetic catalyst (Fe3O4@S–TiO2) was prepared by the hydrothermal method. At the first, Fe3O4 nanoparticles were synthesized, then iron oxide nanoparticles (IONPs) were dispersed in ethano

Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells

To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy.

Ir-Catalyzed C?H Amidation of Aldehydes with Stoichiometric/Catalytic Directing Group

Ir-catalyzed sp2C?H amidation of aldehydes with various anilines as stoichiometric or catalytic directing groups was accomplished. A wide range of substrates were selectively amidated in good to excellent yields with broad functional group tolerance. The iridacycle complexes were isolated, characterized, and proved as key intermediates. Kinetic studies and Hammett plots provided detailed understandings of this amidation. According to the mechanism, the electron-rich ArSO2N3was proved effective for intermolecular sp3C?H amidation.