53458-16-5Relevant articles and documents
Organocatalytic Synthesis of Substituted Vinylene Carbonates
Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas
supporting information, p. 5129 - 5137 (2021/09/18)
The organocatalytic synthesis of substituted vinylene carbonates from benzoins and acyloins was studied using diphenyl carbonate as a carbonyl source. A range of N-Heterocyclic Carbene (NHC) precursors were screened and it was found that imidazolium salts were the most active for this transformation. The reaction occurs at 90 °C under solvent-free conditions. A wide range of substituted vinylene carbonates (symmetrical and unsymmetrical, aromatic or aliphatic), including some derived from natural products, were prepared with 20–99% isolated yields (24 examples). The reaction was also developed using thermomorphic polyethylene-supported organocatalysts as recoverable and recyclable species. The use of such species facilitates the workup and allows the synthesis of vinylene carbonates on the preparative scale (>30 g after 5 runs). (Figure presented.).
Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source
Shen, Guoli,Liu, Haojie,Chen, Jingchao,He, Zhenxiu,Zhou, Yongyun,Wang, Lin,Luo, Yang,Su, Zhimin,Fan, Baomin
supporting information, p. 3601 - 3610 (2021/05/04)
The zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source and zinc as reductant was successfully conducted. The presented method provides a low-cost, environmentally friendly and practical preparation of α-aryl amino esters, α-hydroxyketones and phenylethylenes. By using D2O as deuterium source, the corresponding products were obtained in high efficiency with excellent deuterium incorporation rate, which gives a cheap and safe tool for access to valuable deuterium-labelled compounds. This journal is
Specific group modified N1 and N3 substituted 4,5-diaryl imidazole ring carbine rhodium complex and preparation method and application thereof
-
Paragraph 0100-0102; 0173; 0189; 0205; 0221, (2019/12/25)
The invention discloses a specific group modified N1 and N3 substituted 4,5-diaryl imidazole ring carbine rhodium complex and a preparation method and application thereof. The structure of the rhodiumcomplex is shown as the formula II (please see the specification for the formula II), wherein R1 is selected from halogen, and C1-4 alkoxy or aryl, R2 is selected from C1-4 alkyl, and substituted ornon-substituted C1-4 alkyl, and a substituent group is selected from an aromatic ring or C3-6 cycloalkyl. In-vivo experiments show that the tumor growth inhibition rate of the rhodium complex under the dosage of 10 mg.kg can reach 45%, and the rhodium complex has the very high tumor growth inhibition capability and high safety, and has good application prospects in the aspect of developing novel non-platinum efficient anticancer drugs.