53599-88-5

Basic information

• Product Name: 4-Chloro-5-nitroisoquinoline
• Synonyms: 4-Chloro-5-nitroisoquinoline
• CAS NO: 53599-88-5
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6012
• Mol File: 53599-88-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-5-nitroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-nitroisoquinoline(53599-88-5)
• EPA Substance Registry System: 4-Chloro-5-nitroisoquinoline(53599-88-5)

Safety Data

• Hazardous Substances Data: 53599-88-5(Hazardous Substances Data)

Upstream product

• 1532-91-8 4-chloroisoquinoline 

Downstream Products

• 651310-21-3 4-chloroisoquinolin-5-amine 
• 194032-34-3 4-chloroisoquinoline-5-sulfonyl chloride 

Relevant articles and documents

ROCK KINASE INHIBITORS

The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

5-Substituted isoquinoline derivatives

A compound represented by the following formula (1) or a salt thereof: wherein R1 represents hydrogen atom, a halogen atom and the like; R2 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; and R3 represents —O—X—C(A1)(A11)—C(A2)(A2l)—N(A3l)(A3)(X represents propylene group etc., A11 and A21 represent hydrogen atom, or a C1-6 alkyl group, A31 represents a C1-6 alkyl group substituted with hydroxyl group, or hydrogen atom, and A1, A2, and A3 represent hydrogen atom, a C1-6 alkyl group and the like) and the like, which has an inhibitory activity on the phosphorylation of myosin regulatory light chain, and is useful for treatment of diseases relating to contraction of various cells and the like.