5367-49-7

Basic information

• Product Name: N-(4-morpholinyl-2-nitrophenyl)acetamide
• Synonyms: N-(4-morpholinyl-2-nitrophenyl)acetamide
• CAS NO: 5367-49-7
• Molecular Weight: 265.269
• Mol File: 5367-49-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-morpholinyl-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-morpholinyl-2-nitrophenyl)acetamide(5367-49-7)
• EPA Substance Registry System: N-(4-morpholinyl-2-nitrophenyl)acetamide(5367-49-7)

Safety Data

• Hazardous Substances Data: 5367-49-7(Hazardous Substances Data)

Upstream product

• 103913-29-7 N-(4-morpholin-4-yl-phenyl)-acetamide 
• 110-91-8 morpholine 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 
• 875-51-4 4-Bromo-2-nitroaniline 
• 881-50-5 N-(4-bromo-2-nitrophenyl)acetamide 

Relevant articles and documents

Heterocycle type derivative and preparing method and pharmaceutical application thereof

The invention relates to a novel heterocycle type derivative, a preparing method thereof, a medicine composition containing the derivative and application of the heterocycle type derivative as therapeutic agent, particularly an FGFR4 inhibitor. The preferable compound has a good inhibiting effect on FGFR4.

Synthesis of meta-substituted aniline derivatives by nucleophilic substitution

Substitution by amines of fluorobenzenes containing a meta- substituted electron withdrawing group (EWG), in DMSO at 100 °C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilisation of the intermediate anion by EWG substituents.