53773-76-5

Basic information

• Product Name: 4'-Methoxy-2'-Methylpropiophenone
• Synonyms: 4'-Methoxy-2'-Methylpropiophenone;1-Propanone, 1-(4-methoxy-2-methylphenyl)-;4-Methoxy-2-Methylpropiophenone(WX626032);1-(4-METHOXY-2-METHYLPHENYL)PROPAN-1-ONE
• CAS NO: 53773-76-5
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 53773-76-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 43°C
• Appearance: /
• CAS DataBase Reference: 4'-Methoxy-2'-Methylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Methoxy-2'-Methylpropiophenone(53773-76-5)
• EPA Substance Registry System: 4'-Methoxy-2'-Methylpropiophenone(53773-76-5)

Safety Data

• Hazardous Substances Data: 53773-76-5(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of propionyl chloride with 3-methylanisole in the presence of aluminium chloride in methylene chloride for 3 h at 0°, in carbon disulfide at r.t. for 24 h (52%) or by Friedel–Crafts acylation using samarium triiodide.

Upstream product

• 79-03-8 propionyl chloride 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 123-62-6 propionic acid anhydride 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 53773-75-4 1-(4-methoxy-2-methyl-phenyl)-propan-1-ol 
• 1609581-97-6 5-(4-hydroxy-2-methylphenyl)-6-methyl-1,2,4-triazin-3(2H)-one 
• 1609581-89-6 6-(4-hydroxy-2-methylphenyl)-5-methylpyrazin-2-ol 
• 1609581-53-4 4-(4-methoxy-2-methylphenyl)-3-methylimidazo[2,1-c][1,2,4]triazine 
• 1609259-39-3 6-(4-hydroxy-2-methylphenyl)-1,5-dimethylpyrazin-2(1H)-one 
• 1609259-38-2 6-(4-methoxy-2-methylphenyl)-1,5-dimethylpyrazin-2(1H)-one 
• 1609259-37-1 6-(4-methoxy-2-methylphenyl)-5-methylpyrazin-2(1H)-one 
• 1609259-36-0 1-(4-methoxy-2-methylphenyl)propane-1,2-dione 
• 121347-32-8 2-(hydroxyimino)-1-(4-methoxy-2-methylphenyl)propan-1-one 
• 1609581-19-2 3-(dimethylamino)-1-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-2-methylprop-2-en-1-one 
• 1609581-18-1 1-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]propan-1-one 
• 2887-55-0 1-(4-hydroxy-2-methylphenyl)propan-1-one 
• 1609577-29-8 4-(4-(1-(tert-butyl)-4-methyl-1H-pyrazol-5-yl)-3-methylphenoxy)furo[3,2-c]pyridine 
• 1609579-46-5 6-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-1,5-dimethylpyrimidin-2(1H)-one 

Relevant articles and documents

HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β- arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Catalytic Friedel-Crafts acylation of aromatic ethers using Sml3

10% mol Sml3 catalysed the Friedel-Crafts acylation of aromatic ethers by acyl chlorides in acetonitrile with the yields of 48-82%. Reactions of various substituted aromatic ethers with acyl chloride were studied. The structures of compounds were established by IR and 1H NMR. The main product obtained with anisole is the para-substituted compound with only a trace (3, a pattern repeated with the other aromatic ethers used.