53917-01-4

Basic information

• Product Name: 2-Butanone, 1-(4-methoxyphenyl)-
• Synonyms: 2-Butanone, 1-(4-methoxyphenyl)-;1-(4-Methoxyphenyl)-2-butanone;1-(4-Methoxyphenyl)butan-2-one
• CAS NO: 53917-01-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 53917-01-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 268.3 °C at 760 mmHg
• Flash Point: 109.8 °C
• Appearance: /
• Density: 1.010
• Vapor Pressure: 0.00777mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 2-Butanone, 1-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 1-(4-methoxyphenyl)-(53917-01-4)
• EPA Substance Registry System: 2-Butanone, 1-(4-methoxyphenyl)-(53917-01-4)

Safety Data

• Hazardous Substances Data: 53917-01-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5655, 1955 DOI: 10.1021/ja01626a056

InChI:InChI=1/C11H14O2/c1-3-10(12)8-9-4-6-11(13-2)7-5-9/h4-7H,3,8H2,1-2H3

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 71017-75-9 1-(4-methoxybenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt 
• 123-38-6 propionaldehyde 
• 104-93-8 p-methylanizole 
• 18322-84-4 (E)-1-(but-2-en-1-yl)-4-methoxybenzene 
• 104-01-8 4-Methoxyphenylacetic acid 
• 557-20-0 diethylzinc 
• 110661-90-0 1-(4-methoxyphenyl)-2-butanol 
• 857590-49-9 4-(1,2-dibromo-butyl)-anisole 
• 39831-53-3 1-(but-2-en-1-yl)-4-methoxybenzene 
• 104-47-2 p-methoxybenzylnitrile 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 109368-12-9 ethyl 2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylate 

Downstream Products

• 866021-05-8 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene 
• 878551-75-8 (+/-)-1,3-diethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene 
• 866021-06-9 (+/-)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxylic acid 
• 878551-33-8 (+/-)-3-ethyl-N-(4-hydroxyphenyl)-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide 
• 878648-67-0 (+/-)-N-(4-(2-(dimethylamino)ethoxy)phenyl)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide 
• 120551-19-1 3-ethyl-2-(4-hydroxy-phenyl)-inden-6-ol 
• 115217-07-7 Ethyl indenestrol A 
• 97968-26-8 2-Ethyl-6-methoxy-3-(4-methoxy-phenyl)-1-methyl-1H-indole 
• 97968-23-5 2-Ethyl-5-methoxy-3-(4-methoxy-phenyl)-1-methyl-1H-indole 
• 97968-27-9 1,2-Diethyl-6-methoxy-3-(4-methoxy-phenyl)-1H-indole 
• 97968-28-0 2-Ethyl-6-methoxy-3-(4-methoxy-phenyl)-1-propyl-1H-indole 
• 97968-35-9 Acetic acid 3-(4-acetoxy-phenyl)-2-ethyl-1-methyl-1H-indol-6-yl ester 
• 97968-32-6 Acetic acid 3-(4-acetoxy-phenyl)-2-ethyl-1-methyl-1H-indol-5-yl ester 
• 97968-36-0 Acetic acid 3-(4-acetoxy-phenyl)-1,2-diethyl-1H-indol-6-yl ester 

Relevant articles and documents

C-H Alkylation of Aldehydes by Merging TBADT Hydrogen Atom Transfer with Nickel Catalysis

Catalyst controlled site-selective C-H functionalization is a challenging but powerful tool in organic synthesis. Polarity-matched and sterically controlled hydrogen atom transfer (HAT) provides an excellent opportunity for site-selective functionalization. As such, the dual Ni/photoredox system was successfully employed to generate acyl radicals from aldehydes via selective formyl C-H activation and subsequently cross-coupled to generate ketones, a ubiquitous structural motif present in the vast majority of natural and bioactive molecules. However, only a handful of examples that are constrained to the use of aryl halides are developed. Given the wide availability of amines, we developed a cross-coupling reaction via C-N bond cleavage using the economic nickel and TBADT catalyst for the first time. A range of alkyl and aryl aldehydes were cross-coupled with benzylic and allylic pyridinium salts to afford ketones with a broad spectrum of functional group tolerance. High regioselectivity toward formyl C-H bonds even in the presence of α-methylene carbonyl or α-amino/oxy methylene was obtained.

Regioselective Isomerization of 2,3-Disubstituted Epoxides to Ketones: An Alternative to the Wacker Oxidation of Internal Alkenes

We report an alternative pathway to the Wacker oxidation of internal olefins involving epoxidation of trans-alkenes followed by a mild and highly regioselective isomerization to give the major ketone isomers in 66-98% yield. Preliminary kinetics and isotope labeling studies suggest epoxide ring opening as the turnover limiting step in our proposed mechanism. A similar catalytic system was applied to the kinetic resolution of select trans-epoxides to give synthetically useful selectivity factors of 17-23 for benzyl-substituted substrates.

NOVEL THIENOPYRIMIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel thienopyrimidine derivative having an excellent anti? inflammatory and anti-cancer activity, or a pharmaceutically acceptable salt thereof, a process for the preparation thereof and a pharmaceutical composition comprising the same. The compound according to the present invention strongly inhibits IKB kinase-β (IKK-β) involved in the activation of a transcriptional factor, NF-κB, which is associated with inducing various immune and inflammatory diseases, whereby a composition comprising the compound is a useful therapeutic agent against inflammatory diseases, in particular, arthritis and cancer.