53948-07-5 Usage
Description
ARISTOLACTAM-AII is a chemical compound belonging to the aristolactam family, commonly found in various plants. It is a potent nephrotoxin and carcinogen, with exposure linked to the development of kidney and urinary tract cancers. ARISTOLACTAM-AII forms DNA adducts that can lead to mutations and tumor formation, and has been used as a model compound for studying chemical carcinogenesis. It is also identified as a potential cause of aristolochic acid nephropathy, a serious kidney disease associated with the ingestion of plants containing aristolochic acid.
Uses
Used in Pharmaceutical Research:
ARISTOLACTAM-AII is used as a model compound for studying the mechanisms of chemical carcinogenesis, aiding in the development of potential treatments and preventive measures against cancer.
Used in Toxicology Studies:
ARISTOLACTAM-AII is utilized in toxicology research to understand the effects of nephrotoxins and carcinogens on the human body, particularly in the context of kidney and urinary tract cancers.
Used in Public Health Efforts:
Efforts are being made to mitigate exposure to ARISTOLACTAM-AII and other aristolactam compounds in order to protect public health, particularly in relation to aristolochic acid nephropathy and associated kidney diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 53948-07-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,9,4 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 53948-07:
(7*5)+(6*3)+(5*9)+(4*4)+(3*8)+(2*0)+(1*7)=145
145 % 10 = 5
So 53948-07-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H11NO3/c1-20-15-12(18)7-10-13-11(17-16(10)19)6-8-4-2-3-5-9(8)14(13)15/h2-7,18H,1H3,(H,17,19)
53948-07-5Relevant articles and documents
ARISTOLOLACTAMS OF GONIOTHALAMUS SESQUIPEDALIS WALL. REVISED STRUCTURES OF THE 2-OXYGENATED ARISTOLOLACTAMS
Talapatra, Sunil K.,Basu, Dipankar,Chattopadhyay, Pratap,Talapatra, Bani
, p. 903 - 906 (1988)
Key Word Index-Goniothalamus sesquipedalis; Annonaceae; aristololactams; goniopedaline; (13)C NMR; revised structures of 2-oxygenated aristololactams.Goniopedaline, a new phenathrene lactam, aristololactam A-II and its N,O-diacetyl derivative, taliscanine (second natural occurence), aurantiamide acetate and β-sitosterol and its β-D-glucoside have been isolated from the leaves and twigs of Goniothalamus sesquipedalis.The structure of goniopedaline has been established from its spectral evidence as 10-amino-3-hydroxy-2,4-dimethoxyphenathrene-1-carboxylic acid lactam.The structures of aristololactam CII, CIII, DII and DIII have been revised from the previously suggested 3-hydroxymethyl-2-methoxy derivatives and the 3-carboxy-2-hydroxy derivatives to the 2-hydroxymethyl-3-methoxy derivatives and the 2-carboxy-3-hydroxy derivatives respectively based on a careful analysis of their (13)C NMR spectral data.Thus, goniopedaline is the only 2-oxygenated aristololactam known so far.This constitutes the first report of the phenanthrene lactams from the Goniothalamus genus.
