5397-27-3

Basic information

• Product Name: tert-butyl 3-hydroxy-3-phenylpropanoate
• Synonyms: Propanoic acid, 3-hydroxy-3-phenyl-, t-butyl ester; tert-Butyl 3-hydroxy-3-phenylpropanoate
• CAS NO: 5397-27-3
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.2802
• Mol File: 5397-27-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 332.1°C at 760 mmHg
• Flash Point: 134.7°C
• Density: 1.076g/cm³
• Vapor Pressure: 5.93E-05mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: tert-butyl 3-hydroxy-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-hydroxy-3-phenylpropanoate(5397-27-3)
• EPA Substance Registry System: tert-butyl 3-hydroxy-3-phenylpropanoate(5397-27-3)

Safety Data

• Hazardous Substances Data: 5397-27-3(Hazardous Substances Data)

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 100-52-7 benzaldehyde 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 762-75-4 tert-butyl formate 
• 98-83-9 isopropenylbenzene 
• 93215-51-1 1-tert-butoxy-1-(trimethylsiloxy)ethylene 
• 49827-15-8 t-butyl iodoacetate 
• 51656-70-3 (2-tert-butoxy-2-oxoethyl)zinc(II) bromide 
• 42052-52-8 1-hydroxy-4,4-dimethyl-1-phenylpentan-3-one 
• 91157-51-6 5-Phenyl-3-tert-butyl-Δ²-isoxazoline 

Downstream Products

• 14990-09-1 tert-butyl cinnamate 
• 52178-62-8 (-) S-β-hydroxy β-phenyl propionate de t-butyle 
• 72656-48-5 tert-butyl (R)-3-hydroxy-3-phenylpropanoate 
• 1155875-09-4 tert-butyl 2-benzyl-2-fluoro-3-oxo-3-phenylpropanoate 
• 642098-17-7 tert-butyl 2-fluoro-2-methyl-3-oxo-3-phenylpropanoate 
• 359887-29-9 tert-butyl 2-benzyl-3-oxo-3-phenylpropanoate 
• 104015-38-5 tert-butyl 2-benzoylpropionate 
• 847776-97-0 tert-butyl 3-phenyl-2H-azirine-2-carboxylate 

Relevant articles and documents

Visible-Light-Driven, Metal-Free Divergent Difunctionalization of Alkenes Using Alkyl Formates

In recent decades, difunctionalization of alkenes has received considerable attention as an efficient and straightforward way to increase molecular complexity. However, examples of the difunctionalization of alkenes initiated by the intermolecular addition of alkoxycarbonyl radicals providing substituted alkanoates are still rare. Herein, we present the visible light-driven metal-free divergent difunctionalization of alkenes triggered by the intermolecular addition of alkoxycarbonyl radicals under ambient conditions. Employing alkyl formates as precursors of alkoxycarbonyl radicals and 4CzIPN as the photocatalyst, a variety of substituted alkanoates, including β-alkoxy, β-hydroxy, β-dimethoxymethoxy, and β-formyloxy alkanoates, could be facilely accessed with high functional group tolerance and high efficiency. Moreover, the mechanism study revealed that β-hydroxy alkanoates were generated by a selective decomposition of orthoformates promoted by the N-alkoxyazinium salt.

Asymmetric Synthesis of α-Chloro-α-halo Ketones by Decarboxylative Chlorination of α-Halo-β-ketocarboxylic Acids

Chiral α-chloro-α-fluoro ketones were synthesized by enantio-selective decarboxylative chlorination of α-chloro-β-ketocarboxylic acids in the presence of a chiral amine catalyst. The reaction yielded the corresponding α-chloro-α-fluoro ketones with modera

Gold-catalyzed synthesis of functionalized pyridines by using 2H-azirines as synthetic equivalents of alkenyl nitrenes

2H-Azirines are easily synthesized from the corresponding ketones and, despite possessing a C=N bond embedded in a strained three-membered cycle, they are sufficiently stable to be isolated, stored, and manipulated. 2H-Azirines can be regarded as valuable