53992-31-7

Basic information

• Product Name: C-(4-nitrophenyl)-N-phenylmethanesulfonamide
• Synonyms: C-(4-nitrophenyl)-N-phenylmethanesulfonamide
• CAS NO: 53992-31-7
• Molecular Weight: 292.315
• Mol File: 53992-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C-(4-nitrophenyl)-N-phenylmethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: C-(4-nitrophenyl)-N-phenylmethanesulfonamide(53992-31-7)
• EPA Substance Registry System: C-(4-nitrophenyl)-N-phenylmethanesulfonamide(53992-31-7)

Safety Data

• Hazardous Substances Data: 53992-31-7(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 110661-61-5 (p-nitrophenyl)methanesulfonyl fluoride 

Downstream Products

• 88918-86-9 C-(4-aminophenyl)-N-phenylmethanesulfonamide 

Relevant articles and documents

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Nucleophilic Substitution Reaction of Phenylmethanesulfonyl Halides with Anilines

Kinetic studies on the nucleophilic substitution reaction of Y-substituted phenylmethanesulfonyl halides with X-substituted anilines in methanol-acetonitrile have been carried out in order to elucidate the reaction mechanism.The phenylmethanesulfonyl fluorides (PSF) had markedly lower rates and smaller magnitudes of ρX and ρY values compared with those for the chlorides (PSC).On the contrary, however, the magnitude of the cross-interaction constant ρXY was greater for PSF than for PSC, so that the degree of bond making in the transition state is actually greater in the reaction of PSF as compared with that for PSC.We have thus demonstrated that extensive charge transfer from a nucleophile to a substrate does not necessarily mean a tight bond in the transition state.Moreover the nonzero ρXY values obtained for both PSC and PSF are taken as evidence in support of a common, associative SN2 mechanism for the two halides.