54-12-6 Usage
Description
DL-Tryptophan, an essential α-amino acid, is the precursor for 5-hydroxy-tryptamin (serotonin) and melatonin. It exists as a zwitterion during crystallization and is characterized by its white crystal form. DL-Tryptophan is slightly soluble in water, stable in alkaline solutions, and decomposes when exposed to strong acids.
Uses
Used in Pharmaceutical Applications:
DL-Tryptophan is used as an amino acid precursor for the synthesis of serotonin and melatonin, which play crucial roles in regulating mood, sleep, and other physiological functions. It is utilized as a dietary supplement for its antidepressant, anxiolytic, and sleep aid properties, helping to alleviate symptoms of depression, anxiety, and insomnia.
Used in Nutritional Supplements:
As a dietary supplement, DL-Tryptophan is used to support overall health and well-being by promoting the production of essential neurotransmitters. It can be found in various health and wellness products, targeting individuals seeking natural alternatives to manage stress, improve sleep quality, and enhance mood regulation.
Used in Animal Nutrition:
DL-Tryptophan is used as a feed nutrition enhancer in the animal industry, contributing to the overall health and productivity of livestock. It plays a vital role in the synthesis of proteins and other essential biomolecules, supporting the growth and development of animals.
Used in Antioxidant Formulations:
Due to its chemical properties, DL-Tryptophan can also be used as an antioxidant in various applications. It helps protect cells from oxidative damage, which can be beneficial in the development of nutraceuticals and other health-related products.
Biochem/physiol Actions
DL-Tryptophan binding to bovine serum albumin is employed for its affinity based chromatographic purification. Supplementation of tryptophan in diets of rat induce bladder tumor.
Safety Profile
Experimental
reproductive effects. Questionable
carcinogen with experimental carcinogenic
data. When heated to decomposition it
emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 54-12-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 54-12:
(4*5)+(3*4)+(2*1)+(1*2)=36
36 % 10 = 6
So 54-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)
54-12-6Relevant articles and documents
Dynamic Kinetic Resolution for Asymmetric Synthesis of L-Noncanonical Amino Acids from D-Ser Using Tryptophan Synthase and Alanine Racemase
Yu, Jinhai,Li, Jing,Gao, Xia,Zeng, Shuiyun,Zhang, Hongjuan,Liu, Junzhong,Jiao, Qingcai
, p. 6618 - 6625 (2019/11/03)
L-Ser is often used to synthesize some significant l-noncanonical α-amino acids(l-ncAAs), which are the prevalent intermediates and precursors for functional synthetic compounds. In this study, threonine aldolase from Escherichia coli k-12 MG1655 has been used to synthesize l-Ser. In contrast to the maximum catalytic capacity (20 g/L) for l-threonine aldolase(LTA), d-Ser was synthesized with high yield (240 g/L) from cheap Gly and paraformaldehyde using d-threonine aldolase (DTA) from Arthrobacter sp ATCC. In order to fully utilize d-Ser and expand the resource of l-Ser, a dynamic kinetic resolution system was constructed to convert d/dl-Ser to l-Ser through combining alanine racemase (Alr) from Bacillus subtilis with l-tryptophan synthase (TrpS) from Escherichia coli k-12 MG1655, and l-ncAAs including l-Trp and l-Cys derivatives were synthesized with excellent enantioselectivity and in high yields. The results indicated l-ncAAs could be efficiently synthesized from d-Ser using this original and green dynamic kinetic resolution system, and the reliable l-Ser resource has been established from simple and achiral substrates.
Feed additive method for preparing DL-tryptophan
-
Paragraph 0027; 0037; 0038, (2016/10/07)
The invention provides a method for preparing a feed additive DL-tryptophan. The method comprises the following steps of: 1) preparing indole-3-formaldehyde; 2) preparing aceturic acid; 3) preparing 3-indolyl-2-acetamino acrylic acid; 4) preparing N-acetyltryptophan; 5) preparing the DL-tryptophan. The method for preparing the feed additive DL-tryptophan is easy in acquisition of raw materials, low in raw material cost, high in reaction efficiency, and simple in process; the method can be carried out at the normal temperature and under the normal pressure without environmental pollution.
Peptidomimetics comprising N-amino cyclic urea residues and uses thereof
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Page/Page column, (2015/04/15)
Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed. Use of such peptidomimetics for modulating the activity of CD36 or IL-1 receptor in a cell, and for treating CD36- or IL-1-related disease, disorder or condition is also described.