5409-66-5

Basic information

• Product Name: (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone
• Synonyms: (4-hydroxy-1-methyl-4-phenylpiperidin-3-yl)-phenylmethanone
• CAS NO: 5409-66-5
• Molecular Formula: C₁₉H₂₁NO₂
• Molecular Weight: 295.38
• Mol File: 5409-66-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 468.9°Cat760mmHg
• Flash Point: 237.4°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 1.35E-09mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone(5409-66-5)
• EPA Substance Registry System: (4-hydroxy-1-methyl-4-phenyl-3-piperidyl)-phenyl-methanone(5409-66-5)

Safety Data

• Hazardous Substances Data: 5409-66-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 14, p. 543, 1949 DOI: 10.1021/jo01156a007

InChI:InChI=1/C19H21NO2/c1-20-13-12-19(22,16-10-6-3-7-11-16)17(14-20)18(21)15-8-4-2-5-9-15/h2-11,17,22H,12-14H2,1H3

Upstream product

• 103756-12-3 3,3’-(methylazanediyl)bis(1-phenylpropan-1-one) 
• 98-86-2 acetophenone 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 593-51-1 methylamine hydrochloride 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 94-38-2 3-diethylamino-1-phenyl-propan-1-one 
• 768-03-6 Phenyl vinyl ketone 
• 74-89-5 methylamine 
• 2298-49-9 N-methyl-3-oxo-N-(3-oxo-3-phenylpropyl)-3-phenylpropan-1-aminium chloride 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 

Downstream Products

• 83266-43-7 β-<4-Nitro-phenylamino>-propiophenon 
• 882769-19-9 C₁₇H₁₇NO₃ 
• 727368-03-8 C₁₇H₁₉NO 
• 156483-65-7 C₁₅H₁₄INO 
• 933217-40-4 C₁₅H₁₄BrNO 
• 57624-47-2 3-(4-bromophenylamino)-1-phenylpropan-1-one 
• 893683-90-4 ethyl 4-(3-oxo-3-phenylpropylamino)benzoate 
• 83266-42-6 β-<3-Nitro-phenylamino>-propiophenon 
• 13788-78-8 1-(2,4-dinitrophenyl)-3-phenylpyrazole 
• 63352-68-1 3-(2-chlorophenylamino)-1-phenylpropan-1-one 
• 83266-41-5 3-[(3-chlorophenyl)amino]-1-phenyl-1-propanone 
• 2983-48-4 1-phenyl-3-(phenylamino)propan-1-one 
• 4173-65-3 3-[(4-methoxyphenyl)amino]-1-phenylpropan-1-one 
• 58153-99-4 3-((4-chlorophenyl)amino)-1-phenylpropan-1-one 

Relevant articles and documents

Exploration of piperidinols as potential antitubercular agents

Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferas

Novel synthesis of 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine

Unusual formation of 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine (3) is reported in the reaction of 3-bromopropiophenone (1) and methylamine.A possible mechanism of the reaction is also reported.