541-22-0 Usage
Description
Decamethonium Bromide, also known as Decamethonium, is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs) and is characterized by its crystalline solid form. Derived from methanol and acetone, Decamethonium Bromide has been utilized in various medical applications due to its ability to activate and inhibit specific receptors.
Uses
Used in Anesthesia:
Decamethonium Bromide is used as a neuromuscular blocking agent for inducing paralysis during anesthesia. It facilitates the process by blocking electrically-evoked muscle twitches, allowing for a smoother and more controlled surgical procedure.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Decamethonium Bromide is used as a research compound for studying the effects on muscle-type and neuronal-type nAChRs. Its ability to activate and inhibit these receptors makes it a valuable tool in understanding the underlying mechanisms of various neurological conditions and developing potential treatments.
Used in Neuromuscular Research:
Decamethonium Bromide is used as a research tool in neuromuscular research to investigate the interactions between the agent and nAChRs. This helps in understanding the role of these receptors in muscle contraction and the potential development of new therapeutic agents for related conditions.
Used in Acetylcholinesterase Inhibition:
Decamethonium Bromide is used as an inhibitor of electric eel acetylcholinesterase (AChE), which is an enzyme responsible for the breakdown of acetylcholine. By inhibiting AChE, Decamethonium Bromide can help in studying the effects of acetylcholine on muscle contraction and neurotransmission.
Biological Functions
Decamethonium was one of the first neuromuscular blocking agents to be synthesized. An SAR study on a series of bis-quaternary ammonium
compounds with varying numbers of methylene groups separating the nitrogen atoms demonstrated that maximal neuromuscular blockade
occurred with 10 to 12 unsubstituted methylene groups. Activity diminished as the number of carbons was either decreased or increased. The
compound with six methylene groups, hexamethonium, is a nicotinic antagonist at autonomic ganglia (ganglionic blocking agent). All the
compounds in this series that possessed neuromuscular blocking activity also caused depolarization of the postjunctional membrane.
Air & Water Reactions
Water soluble.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition DECAMETHONIUM BROMIDE emits very toxic fumes.
Fire Hazard
Flash point data for DECAMETHONIUM BROMIDE are not available. DECAMETHONIUM BROMIDE is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 541-22-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 541-22:
(5*5)+(4*4)+(3*1)+(2*2)+(1*2)=50
50 % 10 = 0
So 541-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6;;/h7-16H2,1-6H3;2*1H/q+2;;/p-2
541-22-0Relevant articles and documents
The bisnaphthalimides as new active lead compounds against Plasmodium falciparum
Tischer, Maximilian,Sologub, Ludmilla,Pradel, Gabriele,Holzgrabe, Ulrike
, p. 2998 - 3003 (2010)
The bisquaternary bisnaphthalimides are a versatile class of compounds being active against the malaria parasite Plasmodium falciparum in the lower nanomolar range of concentration combined with no cytotoxicity. The series of compounds is designed as choline analogues and interfering agents of the phosphatidylcholine biosynthesis. The qualitative analysis of the structure-activity relationships (SAR) revealed the importance of a long methylene middle chain of at least 8 methylene groups between the two bisquaternary naphthalimides or a monoquaternary naphthalimide consisting of a long alkyl chain attached to the positively charged nitrogen atom. Since the SARs are different from reported biscationic antimalarial drugs the mode of action remains to be elucidated.
Orientational isomers of α-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads
Baer, Andrew J.,Macartney, Donal H.
, p. 1448 - 1453 (2007/10/03)
Two series of novel dicationic threading molecules [Quin(CH 2)10R]2+ and [3,5-Lut(CH2) 10R]2+, where Quin- = quinuclidinium. 3,5-Lut+ = 3,5-lutidinium, and R+ = N(CH3) 3+ and N(CH3)2CH2CH 3+, form [2]semi-rotaxanes with α-cyclodextrin (α-CD) in aqueous solution. The quinuclidinium and 3.5-lutidinium arc sufficiently bulky to prevent threading while the R+ groups allow for slow threading by α-CD at 25°C. The resulting [2]semi-rotaxanes exist in two orientational isomers owing to the asymmetry of both the α-CD cavity and the threading molecules. Two-dimensional 1H NMR spectroscopy and kinetics experiments reveal that the isomer in which the narrower rim (primary OHs) is positioned near the R+ group is the kinetically preferred isomer, while the other isomer is the thermodynamically preferred product. The kinetics and mechanism of the formation, dissociation, and interconversion of the two isomers have been determined at 25°C. The Royal Society of Chemistry 2005.