54257-94-2

Basic information

• Product Name: Benzene, 1-bromo-2-(chloromethoxy)-
• CAS NO: 54257-94-2
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Mol File: 54257-94-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-2-(chloromethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-(chloromethoxy)-(54257-94-2)
• EPA Substance Registry System: Benzene, 1-bromo-2-(chloromethoxy)-(54257-94-2)

Safety Data

• Hazardous Substances Data: 54257-94-2(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 592508-12-8 1-bromo-2-[(methylsulfanyl)methoxy]benzene 

Downstream Products

• 500131-68-0 (3S,8aR,14bS)-3-phenyl-2,3,5,6,7,8-hexahydro-14bH-chromeno[4,3-b]pyrido[2,1-c][1,4]oxazin-14b-amine 
• 500131-69-1 (3S,8aR,14bS)-3-phenyl-2,3,5,6,7,8-hexahydro-14bH-chromeno[4,3-b]pyrido[2,1-c][1,4]oxazin-14b-ol 
• 500131-67-9 (2R)-2-[(1S,12S)-10-oxa-2,16-diazatetracyclo[10.3.1.0^3,12.0^4,9]hexadeca-2,4⁽⁹⁾,5,7-tetraen-16-yl]-2-phenyl-1-ethanol 
• 592508-14-0 (R)-2-[(6aS,11aR)-(7,8,9,10,11,11a-Hexahydro-5-oxa-11-aza-cyclohepta[a]naphthalen-6a-yl)amino]-2-phenyl-ethanol 
• 90-43-7 2-Phenylphenol 
• 1443418-31-2 C₁₅H₁₃BrO₄ 
• 1443418-26-5 C₁₅H₁₅BrO₂ 
• 1443418-25-4 C₁₃H₁₀BrFO₂ 
• 1443418-24-3 C₁₄H₁₃BrO₃ 
• 1443418-23-2 C₁₃H₁₁BrO₂ 
• 220-11-1 dibenzo[d,f][1,3]dioxepin 
• 1806-29-7 2,2'-dihydroxybiphenyl 
• 1192110-10-3 C₁₃H₁₀Br₂O₂ 

Relevant articles and documents

Formaldehyde-Extruding Homolytic Aromatic Substitution via C→O Transposition: Selective ‘Traceless-Linker’ access to Congested Biaryl Bonds

A new, selective way to form C?C bonds has been developed. In this report, we disclose the homolytic aromatic substitution via C→O transposition coupled with the elimination of formaldehyde (as a traceless linker). Computational analysis indicates the sel

Tethering for selective synthesis of 2,2′-biphenols: The acetal method

2,2'-Biphenols are a large and diverse group of compounds with exceptional properties both as ligands and bioactive agents. Traditional methods for their synthesis by oxidative dimerisation are often problematic and lead to mixtures of ortho- and para-connected regioisomers. To compound these issues, an intermolecular dimerisation strategy is often inappropriate for the synthesis of heterodimers. The 'acetal method' provides a solution for these problems: stepwise tethering of two monomeric phenols enables heterodimer synthesis, enforces ortho regioselectivity and allows relatively facile and selective intramolecular reactions to take place. The resulting dibenzo[1,3]dioxepines have been analysed by quantum chemical calculations to obtain information about the activation barrier for ring flip between the enantiomers. Hydrolytic removal of the dioxepine acetal unit revealed the 2,2′-biphenol target. All tied up! Oxidative dimerisation of phenols often results in regioisomeric mixtures. One solution is the use of an acetal tether to impart ortho reactivity to the hydroxyarenes in a 1:1 ratio. Cyclisation forms dibenzo[1,3]dioxepine intermediates, then cleavage of the acetal linker delivers the unmasked biphenol (see scheme). Copyright

Novel polycyclic heterocycles. XI. Synthesis of 11,12 dihydropyrido [2,1 b] [1,3] benzodiazepines, 6h pyrido[1,2 c] [1,3,5] benzoxadiazepines, and 6h pyrido[1,2 c] [1,3,5]benzothiadiazepines (1)

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