54346-19-9

Basic information

• Product Name: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
• Synonyms: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE;4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(Methylthio)pyrazolo[1;5-a][1;4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine;pyrazolo[1,5-a][1,3,5]triazine
• CAS NO: 54346-19-9
• Molecular Formula: C₆H₅ClN₄S
• Molecular Weight: 200.65
• EINECS: 200-589-5
• Product Categories: CHIRAL CHEMICALS
• Mol File: 54346-19-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 140.8 °C
• Appearance: /
• Density: 1.286 g/cm³
• Refractive Index: 1.782
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.84±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE(54346-19-9)
• EPA Substance Registry System: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE(54346-19-9)

Safety Data

• Hazardous Substances Data: 54346-19-9(Hazardous Substances Data)

Usage

General Description

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE is a chemical compound that belongs to the class of pyrazolo-triazine derivatives. It is a heterocyclic compound containing both sulfur and chlorine atoms, and it is used in the field of organic chemistry for various reactions and synthesis processes. 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE has potential applications in pharmaceuticals and agrochemicals due to its unique structure and properties. It may also be used as a starting material in the synthesis of other complex organic compounds. The exact uses and applications of this compound may vary depending on the specific requirements of different industries and research fields. Overall, 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE is a versatile chemical with potential applications in various areas of scientific and industrial research.

InChI:InChI=1/C6H5ClN4S/c1-12-6-9-4-2-3-8-11(4)5(7)10-6/h2-3H,1H3

Upstream product

• 34682-99-0 2-sulfanylpyrazolo[1,5-a][1,3,5]triazin-4-ol 
• 34683-00-6 N-[(1H-pyrazol-3-ylamino)thioxomethyl]carbamic acid ethyl ester 
• 34683-00-6 ethyl N-[(1H-pyrazol-5-yl)carbamothioyl]carbamate 
• 34682-99-0 2-sulfanylidene-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one 
• 54346-18-8 2-(methylsulfanyl)pyrazolo[1,5-a][1,3,5]triazin-4-ol 
• 54346-18-8 2-(methylsulfanyl)-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one 

Downstream Products

• 515880-10-1 4-(N-methyl-N-phenylamino)-2-(methylsulfanyl)pyrazolo[1,5-a]-1,3,5-triazine 
• 1162654-55-8 4-(N-methyl-N-phenylamino)-2-(methylsulfonyl)pyrazolo[1,5-a]-1,3,5-triazine 
• 1358769-17-1 C₁₉H₂₆N₆O₂ 
• 1358769-19-3 C₂₄H₂₅Br₂N₇O 
• 1358769-23-9 C₂₄H₂₄Br₂ClN₇O 
• 54346-33-7 8-bromo-2-(methylthio)-4-chloropyrazolo<1,5-a>-1,3,5-triazine 
• 1548336-72-6 (S)-2-(1-(2-aminopyrazolo[1,5-a][1,3,5]triazin-4-yl)pyrrolidin-2-yl)-5-chloro-3-phenylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 

Relevant articles and documents

Microwave-assisted sequential one-pot synthesis of 8-substituted pyrazolo[1,5-a][1,3,5]triazines

This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et)2 and alkyl or (het)aryl groups. This study conf

Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action

Despite the availability of hundreds of antibiotic drugs, infectious diseases continue to remain one of the most notorious health issues. In addition, the disparity between the spread of multidrug-resistant pathogens and the development of novel classes of antibiotics exemplify an important unmet medical need that can only be addressed by identifying novel targets. Herein we demonstrate, by the development of the first in vivo active DegS inhibitors based on a pyrazolo[1,5-a]-1,3,5-triazine scaffold, that the serine protease DegS and the cell envelope stress-response pathway σE represent a target for generating antibiotics with a novel mode of action. Moreover, DegS inhibition is synergistic with well-established membrane-perturbing antibiotics, thereby opening promising avenues for rational antibiotic drug design.

PYRAZOLO[1,5-A][1,3,5]TRIAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS CDK INHIBITORS

The present invention provides substituted pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives of formula (I), which are therapeutically useful, particularly as selective transcriptional CDK inhibitors including CDK7, CDK9, CDK12, CDK13 and CDK18, more particularly transcriptional CDK7 inhibitors wherein X, ring A, ring B, L1, L2, R1,R2, R3, R4, R6, m, n and p have the meanings given in the specification and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder associated with selective transcriptional CDKs in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof.