5456-97-3

Basic information

• Product Name: N-butyl-4-methyl-benzamide
• Synonyms: N-butyl-4-methyl-benzamide;N-n-Butyl-4-MethylbenzaMide, 97%
• CAS NO: 5456-97-3
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 5456-97-3.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 334.4°Cat760mmHg
• Flash Point: 199.3°C
• Appearance: /
• Density: 0.977g/cm³
• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: N-butyl-4-methyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-4-methyl-benzamide(5456-97-3)
• EPA Substance Registry System: N-butyl-4-methyl-benzamide(5456-97-3)

Safety Data

• Hazardous Substances Data: 5456-97-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H17NO/c1-3-4-9-13-12(14)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H,13,14)

Upstream product

• 3848-42-8 O-(4-nitrophenyl)-N-(4-tolyl)carbamate 
• 109-73-9 N-butylamine 
• 99-94-5 p-Toluic acid 
• 122-00-9 para-methylacetophenone 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 400-59-9 N-butyl-2,2,2-trifluoroacetamide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 106-38-7 para-bromotoluene 
• 106-45-6 para-thiocresol 
• 6898-75-5 N-isobutylidenebutylamine 
• 102736-23-2 p-Tolyl-carbamic acid 3-nitro-phenyl ester 
• 102736-20-9 p-Tolyl-carbamic acid 4-chloro-phenyl ester 

Downstream Products

• 1303614-32-5 C₁₂H₁₆N₂O₂ 
• 19277-56-6 n-butyl 4-methylbenzoate 

Relevant articles and documents

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Method for synthesizing amide by using methyl arene and amine in water phase

The invention provides a high-efficient method of synthesizing amide with methyl aromatics and amine. In the method, with the methyl aromatics and the amine as the raw materials in the water phase and TBHP and TBAI respectively as an oxidizing agent and a catalyst, a sp3 C-H bond and a sp3 N-H bond are broken and a C-N bond is formed. Compared with a conventional method of synthesizing the amide from oxidized amide, in which an activated acyl group or amine is required, the method is carried out with water as the solvent so that the method is not only economical but also environmental-protective. The method has a very good application prospect in the field of synthesizing polypeptide, protein and drugs in future.

NaOTs-promoted transition metal-free C-N bond cleavage to form C-X (X = N, O, S) bonds

Multifunctional transformation of amide C-N bond cleavage is reported. The protocol applies to benzamide, thioamide, alcohols, and mercaptan under similar reaction conditions catalyzed by NaOTs. It is noteworthy that NaOTs can not only be recycled and reused for up to three cycles without significant loss in catalytic activity, but also catalyze gram-grade reactions. This study provides a novel solution with mild conditions and a simple procedure for transformation of multiple amides.