54562-14-0

Basic information

• Product Name: GAMMA-LINOLENOYL CHLORIDE
• Synonyms: DELTA 6-9-12 CIS-OCTADECATRIENOYL CHLORIDE;GAMMA-LINOLENOYL CHLORIDE;6,9,12-OCTADECATRIENOYL CHLORIDE
• CAS NO: 54562-14-0
• Molecular Formula: C₁₈H₂₉ClO
• Molecular Weight: 296.88
• EINECS: 691-506-6
• Mol File: 54562-14-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 382.86°C at 760 mmHg
• Flash Point: 184.846°C
• Appearance: /
• Density: 0.942g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Refrigerator
• CAS DataBase Reference: GAMMA-LINOLENOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GAMMA-LINOLENOYL CHLORIDE(54562-14-0)
• EPA Substance Registry System: GAMMA-LINOLENOYL CHLORIDE(54562-14-0)

Safety Data

• Hazardous Substances Data: 54562-14-0(Hazardous Substances Data)

Usage

Description

GAMMA-LINOLENOYL CHLORIDE is a chemical compound that serves as an intermediate in the synthesis of various biologically active substances, particularly in the production of γ-Linolenic Acid Ethyl Ester-d5 (L467682), an isotope analog of γ-Linolenic Acid Ethyl Ester. It plays a crucial role in the development of pharmaceuticals and other applications due to its unique properties and reactivity.

Uses

Used in Pharmaceutical Industry:
GAMMA-LINOLENOYL CHLORIDE is used as an intermediate in the synthesis of γ-Linolenic Acid Ethyl Ester-d5 (L467682) for its application in biological studies. This is because γ-Linolenic Acid Ethyl Ester-d5 is employed in the inhibition of neoplasm in cultured carcinoma cells of human breast, contributing to the development of potential cancer treatments.
Used in Biomedical Research:
GAMMA-LINOLENOYL CHLORIDE is used as a precursor in the production of γ-Linolenic Acid Ethyl Ester, which is utilized in the evaluation of hypocholesterolemic activity in rats. This application aids in understanding the potential benefits of γ-Linolenic Acid Ethyl Ester in managing cholesterol levels and its implications for cardiovascular health.

InChI:InChI=1/C18H29ClO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3/b7-6-,10-9-,13-12-

Upstream product

• 506-26-3 all-cis-6,9,12-octadecatrienoic acid 

Downstream Products

• 150314-37-7 linolenyl ethanolamide 
• 183863-63-0 2,2,2-Trichloroethyl 2-[(z,z,z) octadeca-6,9,12-trienoyloxy] benzoate 
• 109791-32-4 ASCORBYL GAMOLENATE 
• 628-13-7 pyridine hydrochloride 
• 847019-77-6 BGC-20-0134 
• 14465-68-0 tri-γ-linolenin 
• 847019-80-1 1,3-di(octadeca-6Z, 9Z, 12Z-enoyloxy)propan-2-one 

Relevant articles and documents

Unsaturation and Polar Head Effect on Gelation, Bioactive Release, and Cr/Cu Removal Ability of Glycolipids

Designing of multifunctional soft and smart materials from natural sources is a useful strategy for producing safer chemicals having potential applications in biomedical research and pharmaceutical industries. Herein, eight glycolipids with variation in unsaturation of hydrophobic tail and polar headgroup size were designed. The effect of unsaturation in the tail group and headgroup size on gelation ability, and mechanical and thermal stability of glycolipid hydro/organogels was studied to understand structure and property relationship. Glycolipids are functional amphiphilic molecules having potential applications in the field of drug delivery and metal removal. The encapsulation capacity and kinetic release behavior of hydrophobic/hydrophilic bioactives like curcumin/riboflavin from the hydrophobic/hydrophilic pockets of glycolipids hydro/organogels was examined. A significant observation was that the glucamine moiety of the glycolipid headgroup plays a vital role in removal of Cr and Cu from oil/water biphasic systems. Typical functions of the glycolipid hydrogels are metal chelation and enzyme-triggered release behavior, enabled them as promising material for Cr, Cu removal from edible oils and controlled release of water soluble/insoluble bioactives.

Transdermal Penetration Enhancer and Their Uses

The present invention relates to a transdermal penetrating enhancer comprising an amino sugar-fatty acid conjugate. The conjugate included in the transdermal penetrating enhancer of the present invention can be industrially used in a cosmetic industry pursuing skin health and aesthetic enhancement of skin, and as well as used as a key material for a formulation of a transdermal drug delivery system. The transdermal penetrating enhancer of the present invention has effect of increasing permeability of a bioactive material or a drug into skin. Also, in some cases, the transdermal penetrating enhancer of the present invention can be applied as a single preparation for the therapeutic purpose by preparing a conjugate including a certain drug. Moreover, since the transdermal penetrating enhancer of the present invention uses a conjugate including a material in which skin safety is ensured, the transdermal penetrating enhancer can be applied to various fields besides a cosmetic or medicinal field.

Chemical compounds

This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives are referred to as “Compounds of formula I” herein. Compounds of formula I can be used in the treatment of a cancerous disease. Treatment of both solid tumours and haematological cancers such as leukaemias, lymphomas and multiple myelomas are included.