54587-91-6

Basic information

• Product Name: 3-((2-aminoethyl)thio)-1,3-diphenylpropan-1-one
• Synonyms: 3-((2-aminoethyl)thio)-1,3-diphenylpropan-1-one
• CAS NO: 54587-91-6
• Molecular Weight: 285.41
• Mol File: 54587-91-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-((2-aminoethyl)thio)-1,3-diphenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((2-aminoethyl)thio)-1,3-diphenylpropan-1-one(54587-91-6)
• EPA Substance Registry System: 3-((2-aminoethyl)thio)-1,3-diphenylpropan-1-one(54587-91-6)

Safety Data

• Hazardous Substances Data: 54587-91-6(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Triethylamin-mediated addition of 2-aminoethanethiol hydrochloride to chalcones: Synthesis of 3-(2-aminoethylthio)-1-(aryl)-3-(thiophen-2-yl) propan-1-ones and 5,7-diaryl-2,3,6, 7-tetrahydro-1,4-thiazepines

The triethylamin-mediated addition of 2-aminoethanethiol hydrochloride to chalcone analogs was investigated. This addition, bearing a 2-thienyl group at the 3-position, gave the only addition adduct at room temperature in 3 h, whereas the chalcones bearing the 2-furyl group at the 1-position gave an addition-cyclization product (1, 4-thiazepine) in the same conditions. The effect of the groups to the reaction was investigated by changing the 1- and 3-position groups. The chalcones bearing the 2-thienyl group at the 1-position and the others afforded the mixture of products in different ratio at rt for 0.5-24 h. Moreover, the addition-cyclization products (1,4-thiazepine) were obtained under reflux conditions in 36 h. The structures of the synthesized compounds were elucidated by 1H NMR, 13C NMR, infrared, and elemental analysis.