54656-96-1

Basic information

• Product Name: (S)-(-)-1-(4-PYRIDYL)ETHANOL
• Synonyms: (S)-(-)-1-(4-PYRIDYL)ETHANOL;(S)-4-(1-HYDROXYETHYL) PYRIDINE;(S)-(-)-ALPHA-METHYL-4-PYRIDINEMETHANOL;(S)-(-)-ALPHA-METHYL-4-PYRIDINEMETHANOL, 99% (98% EE/GLC);(S)-4-(1-Hydroxyethyl)pyridine, (99+% ee), 99+%;(s)-(-)-α-methyl-4-pyridinemethanol;4-AMINOIMIDAZOLE 2HCL;(S)-4-(1-Hydroxyethyl)pyridine, (99+% ee)
• CAS NO: 54656-96-1
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• Product Categories: Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds
• Mol File: 54656-96-1.mol
• Article Data: 71

Chemical Properties

• Melting Point: 67-69 °C(lit.)
• Boiling Point: 239.7±15.0 °C(Predicted)
• Appearance: White/Needles
• Density: 1.082±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator (+4°C)
• Solubility: soluble in Methanol
• PKA: 13.52±0.20(Predicted)
• BRN: 1524527
• CAS DataBase Reference: (S)-(-)-1-(4-PYRIDYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-(4-PYRIDYL)ETHANOL(54656-96-1)
• EPA Substance Registry System: (S)-(-)-1-(4-PYRIDYL)ETHANOL(54656-96-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 54656-96-1(Hazardous Substances Data)

Usage

Description

(S)-(-)-1-(4-PYRIDYL)ETHANOL, also known as (S)-1-(4-Pyridyl)ethanol, is an organic compound with a unique structure that features a pyridyl group attached to an ethanol molecule. It is characterized by its white needle-like crystalline appearance and plays a significant role in the synthesis of various pharmaceutical agents and catalysts.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-1-(4-PYRIDYL)ETHANOL is used as a building block for the synthesis of macrocycles, which are essential in the development of hydrogenation catalysts. These catalysts are crucial in various chemical reactions and processes, contributing to the advancement of the pharmaceutical industry.
Additionally, (S)-(-)-1-(4-PYRIDYL)ETHANOL is utilized in the synthesis of other pharmaceutical agents, highlighting its importance in the development of new drugs and therapies for various medical conditions.
Used in Chemical Industry:
In the chemical industry, (S)-(-)-1-(4-PYRIDYL)ETHANOL serves as a key component in the creation of hydrogenation catalysts. These catalysts are vital in facilitating numerous chemical reactions, leading to the production of various chemicals and materials with diverse applications.
Furthermore, its role in the synthesis of macrocycles and other pharmaceutical agents also extends its utility in the chemical industry, as these compounds can be used in the development of new products and technologies.

InChI:InChI=1/C3H5N3.2ClH/c4-3-1-5-2-6-3;;/h1-2H,4H2,(H,5,6);2*1H

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 4754-27-2 1-(3-Pyridyl)ethanol 
• 23389-75-5 rac-1-(pyridin-4-yl)ethanol 
• 108-05-4 vinyl acetate 
• 2555-02-4 1-(4-Pyridyl)ethyl acetate 
• 66842-22-6 (S)-1-(4-Pyridyl)ethylacetat 
• 866417-96-1 dihydrocinnamic acid 1-pyridin-4-yl-ethyl ester 
• 108-22-5 Isopropenyl acetate 
• 108-24-7 acetic anhydride 
• 141-78-6 ethyl acetate 
• 123-20-6 vinyl n-butyrate 
• 536-75-4 4-Ethylpyridine 
• 54519-07-2 vinyl ester of 3-phenylpropionic acid 
• 330460-83-8 1-(4-Pyridyl)ethyl benzoate 

Downstream Products

• 7782-24-3 (S)-2-Phenylpropionic acid 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 88549-62-6 (S)-2-Phenyl-propionic acid (S)-1-pyridin-4-yl-ethyl ester 
• 97985-14-3 (R)-2-Phenyl-propionic acid (R)-1-pyridin-4-yl-ethyl ester 
• 1129-46-0 (R)-(+)-2-phenoxypropionic acid 
• 1912-23-8 (S)-2-phenoxypropanoic acid 
• 94559-16-7 (S)-2-Phenoxy-propionic acid (S)-1-pyridin-4-yl-ethyl ester 
• 94559-15-6 (R)-2-Phenoxy-propionic acid (S)-1-pyridin-4-yl-ethyl ester 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 23979-41-1 (R)-2-(6-methoxy-2-naphthyl)propionic acid 
• 27854-88-2 (R)-1-(4-pyridinyl)ethanol 
• 1032824-43-3 2-[((1S)-1-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}ethyl)oxy]-5-[4-(methylsulfonyl)phenyl]pyrazine 
• 1313877-65-4 (S,S,S)-C₆H₃(O(CH₂)4C₂HN₃CH₂OCH(CH₃)C₅H₄N)3 
• 561024-34-8 2,2,2-Trichloro-acetimidic acid (S)-1-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethyl ester 

Relevant articles and documents

Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones

Most ligands applied for asymmetric hydrogenation are synthesized via multistep reactions with expensive chemical reagents. Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands have been developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones have been hydrogenated, all affording valuable chiral alcohols with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, and DFT, and an activating model involving trihydride was verified.

Ferrocene derivative metal organic complex as well as preparation method and application thereof

The invention relates to the technical field of organic synthesis, in particular to a ferrocene derivative metal organic complex and a preparation method and application thereof. The ferrocene derivative metal organic complex disclosed by the invention is shown I, contains a pincerlike ligand in the structure, and therefore has high stability and long service life. , The ferrocene derivative type metal organic complex has high catalytic activity, and only 0.001 μM % - 0.01 μM % is used, so that the chiral compound can be efficiently and rapidly prepared. The ferrocene derivative metal organic complex central metal is ruthenium, the economic cost is low, and the method has the prospect of industrial popularization.

Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride

Enzymatic reactions through mononuclear metal hydrides are unknown in nature, despite the prevalence of such intermediates in the reactions of synthetic transition-metal catalysts. If metalloenzymes could react through abiotic intermediates like these, then the scope of enzyme-catalysed reactions would expand. Here we show that zinc-containing carbonic anhydrase enzymes catalyse hydride transfers from silanes to ketones with high enantioselectivity. We report mechanistic data providing strong evidence that the process involves a mononuclear zinc hydride. This work shows that abiotic silanes can act as reducing equivalents in an enzyme-catalysed process and that monomeric hydrides of electropositive metals, which are typically unstable in protic environments, can be catalytic intermediates in enzymatic processes. Overall, this work bridges a gap between the types of transformation in molecular catalysis and biocatalysis. [Figure not available: see fulltext.]