54681-67-3Relevant articles and documents
Stereoselective synthesis of dehydroamino acids using malonic acid half oxyester and aromatic aldehydes
Singjunla, Yuttapong,Colombano, Silvia,Baudoux, Jér?me,Rouden, Jacques
, p. 2369 - 2375 (2016/04/26)
An efficient and direct approach was developed for the synthesis of α,β-dehydroamino acid derivatives with a broad range of substrates. Amido-substituted Malonic Acid Half Oxyesters (MAHOs) have proven to be excellent partners of various aromatic aldehyde
MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE
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Page/Page column 54, (2009/10/09)
The invention provides compounds inhibitory to the Hepatitis C viral protease, compositions and combinations including the compounds, methods of treatment of conditions wherein inhibition of the Hepatitis C viral protease is medically indicated, and metho
Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans
Faucher, Anne-Marie,Bailey, Murray D.,Beaulieu, Pierre L.,Brochu, Christian,Duceppe, Jean-Simon,Ferland, Jean-Marie,Ghiro, Elise,Gorys, Vida,Halmos, Ted,Kawai, Stephen H.,Poirier, Martin,Simoneau, Bruno,Tsantrizos, Youla S.,Llinas-Brunet, Montse
, p. 2901 - 2904 (2007/10/03)
(Equation Presented) The synthesis of BILN 2061, an NS3 protease inhibitor with proven antiviral effect in humans, was accomplished in a convergent manner from four building blocks. The procedure described here was suitable for the preparation of multigra