548740-06-3

Basic information

• Product Name: 3,5-bis(trifluoromethyl)phenyl vinyl sulfone
• Synonyms: 3,5-bis(trifluoromethyl)phenyl vinyl sulfone
• CAS NO: 548740-06-3
• Molecular Weight: 304.213
• Mol File: 548740-06-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-bis(trifluoromethyl)phenyl vinyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(trifluoromethyl)phenyl vinyl sulfone(548740-06-3)
• EPA Substance Registry System: 3,5-bis(trifluoromethyl)phenyl vinyl sulfone(548740-06-3)

Safety Data

• Hazardous Substances Data: 548740-06-3(Hazardous Substances Data)

Upstream product

• 548740-10-9 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl butyrate 
• 548740-11-0 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2-bromopropanoate 
• 548739-97-5 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate 
• 548740-14-3 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2-aminonicotinate 
• 548739-96-4 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 3-phenylpropanoate 
• 548740-12-1 2-[2-(4-cyanophenylcarbonyloxy)ethylsulfonyl]-3,5-di(trifluoromethyl)benzene 
• 548740-13-2 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2,4-dimethoxybenzoate 
• 548740-15-4 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (L)-N-(tert-butyloxycarbonyl)alaninate 
• 548740-19-8 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2-(4-chloro-2-methylphenoxy)propanoate 
• 548740-18-7 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 2-(6-methoxy-2-naphthyl)propanoate 
• 548740-16-5 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl 4-(1,5-dihydro-6-pyrenyl)butanoate 
• 548740-17-6 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl N-(9-fluorenylmethyloxycarbonyl)phenylalanine 
• 130783-02-7 3,5-bis(trifluoromethyl)thiophenol 
• 450409-97-9 2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol 

Downstream Products

• 860644-86-6 C₁₈H₁₇F₆NO₄S 

Relevant articles and documents

Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments

Targeted covalent inhibition and the use of irreversible chemical probes are important strategies in chemical biology and drug discovery. To date, the availability and reactivity of cysteine residues amenable for covalent targeting have been evaluated by proteomic and computational tools. Herein, we present a toolbox of fragments containing a 3,5-bis(trifluoromethyl)phenyl core that was equipped with chemically diverse electrophilic warheads showing a range of reactivities. We characterized the library members for their reactivity, aqueous stability and specificity for nucleophilic amino acids. By screening this library against a set of enzymes amenable for covalent inhibition, we showed that this approach experimentally characterized the accessibility and reactivity of targeted cysteines. Interesting covalent fragment hits were obtained for all investigated cysteine-containing enzymes.

π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids

Several π-deficient 2-(arylsulfonyl)ethyl groups have been studied as carboxylic acid protecting groups. The 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl group is the most easily removed protecting group for acids under mild basic conditions using aqueous NaHCO3.