54901-09-6 Usage
Description
3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER, also known as Ethyl 3-(3,5-Dimethoxyphenyl)propionate, is an organic compound with the chemical formula C12H16O4. It is a colorless to pale yellow liquid with a mild, fruity odor. 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER is characterized by its ester functional group and two methoxy groups on the phenyl ring, which contribute to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER is used as a synthetic reagent for the development of highly potent pan-fibroblast growth factor receptor (FGFR) inhibitors. These inhibitors play a crucial role in the treatment of various diseases, including cancer, by targeting the FGFR signaling pathway, which is often dysregulated in these conditions.
Used in Biochemical Research:
In the field of biochemical research, 3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER is utilized as a reagent in the preparation of selective inhibitors of the FGFR tyrosine kinase. These inhibitors are essential tools for studying the function and regulation of FGFRs, which are involved in cell proliferation, differentiation, and migration. By selectively inhibiting these kinases, researchers can gain insights into the underlying mechanisms of diseases and identify potential therapeutic targets.
Used in Chemical Synthesis:
3-(3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER is also employed as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structural features make it a valuable building block for the development of novel molecules with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 54901-09-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,9,0 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 54901-09:
(7*5)+(6*4)+(5*9)+(4*0)+(3*1)+(2*0)+(1*9)=116
116 % 10 = 6
So 54901-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H18O4/c1-4-17-13(14)6-5-10-7-11(15-2)9-12(8-10)16-3/h7-9H,4-6H2,1-3H3
54901-09-6Relevant articles and documents
Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative
-
Paragraph 0214-0216, (2021/03/06)
The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.
Asymmetric total synthesis of dihydroisocoumarins: 6-methoxymellein, kigelin and fusarentin 6, 7 dimethyl ether by employing proline catalysed asymmetric α-aminoxylation
Mane, Baliram B.,Markad, Sachin B.,Waghmode, Suresh B.
, (2020/10/19)
A concise asymmetric total synthesis of dihydroisocoumarins such as 6-methoxymellein, kigelin and fusarentin 6,7-dimethyl ether in high enantiopurity have been achieved from non-chiral aldehydes by employing proline catalysed asymmetric α-aminoxylation reaction. The required stereochemistry of hydroxyl group have been generated by alternating L or D proline as a organocatalyst in α-aminoxylation step and lactone ring is assembled by oxa-Pictet-Spengler cyclisation reaction as the key steps.
A convenient and effective synthesis of 3-(3,5-dimethoxyphenyl)propanal
Nikas, Spyros P.,Thakur, Ganesh A.,Makriyannis, Alexandros
, p. 1751 - 1756 (2007/10/03)
A convenient and effective synthesis of 3-(3,5-dimethoxyphenyl) propanal, an important intermediate in the synthesis of various biologically active compounds is described.
