54920-84-2

Basic information

• Product Name: 1,7-Naphthyridin-2-amine
• Synonyms: 1,7-Naphthyridin-2-amine
• CAS NO: 54920-84-2
• Molecular Formula: C8H7N3
• Molecular Weight: 145.16
• Mol File: 54920-84-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 342.156 °C at 760 mmHg
• Flash Point: 187.473 °C
• Appearance: /
• Density: 1.293 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,7-Naphthyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Naphthyridin-2-amine(54920-84-2)
• EPA Substance Registry System: 1,7-Naphthyridin-2-amine(54920-84-2)

Safety Data

• Hazardous Substances Data: 54920-84-2(Hazardous Substances Data)

Usage

General Description

1,7-Naphthyridin-2-amine is a chemical compound with the molecular formula C9H8N2. It is a heterocyclic amine that contains a naphthyridine ring structure. 1,7-Naphthyridin-2-amine is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and active pharmaceutical ingredients. It is also used as a building block in organic synthesis for the preparation of other chemical compounds. 1,7-Naphthyridin-2-amine has potential applications in medicinal chemistry and drug discovery due to its unique structure and reactivity. However, it is important to handle this compound with care and follow proper safety guidelines when working with it in a laboratory setting.

Upstream product

• 253-69-0 [1,7]naphthyridine 

Relevant articles and documents

Chichibabin Amination of 1,X-Naphthyridines. Nuclear Magnetic Resonance Studies on the ? Adducts of Heterocyclic Systems with Nucleophiles

In the amination of 1,X-naphthyridines with potassium amide in liquid ammonia at about -35 to -40 deg C the initial adduct formation is charge controlled.Thus, at these temperatures the site with the lowest electron density is most susceptible for amide attack (C-2 in 1,5-naphthyridine, C-2 in 1,6-naphthyridine, C-2 and C-8 in 1,7-naphthyridine, and C-2 in 1,8-naphthyridine), as proven by NMR spectroscopy.When the temperature was raised to about 10 deg C, the site of addition has been found to change for 1,5- and 1,7-naphthyridine (NMR spectroscopy): from C-2 to C-4 in 1,5-naphthyridine and from C-2 and C-8 to C-8 only in 1,7-naphthyridine.In case of 1,6- and 1,8-naphthyridines no change was observed.Thus, the amination at about 10 deg C is a process which is thermodynamically controlled.The several factors which contribute to the stability of these addition products have been discussed.It has been found that the anionic ? adducts 2(4,8)-aminodihydro-1,X-naphthyridinides can be easily oxidized with potassium permanganate into their corresponding 2(4,8)-amino-1,X-naphthyridines.