55245-43-7 Usage
Description
N-(4-chlorobenzyl)-N-propylamine is an organic compound with the molecular formula C10H14ClN. It is a derivative of propylamine, featuring a 4-chlorobenzyl group attached to the nitrogen atom. N-(4-chlorobenzyl)-N-propylamine is known for its reactivity and is commonly utilized in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
N-(4-chlorobenzyl)-N-propylamine is used as a reactant for the preparation of benzolactams. These benzolactams are important intermediates in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of neurological disorders and other medical conditions. The carbonylation of benzylic amines or phenethylamines in the presence of Pd(OAc)2-Cu(OAc)2-air facilitates the formation of these valuable intermediates.
Used in Chemical Synthesis:
In the field of chemical synthesis, N-(4-chlorobenzyl)-N-propylamine serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and functional groups make it a valuable component in the development of new materials, dyes, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 55245-43-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,4 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55245-43:
(7*5)+(6*5)+(5*2)+(4*4)+(3*5)+(2*4)+(1*3)=117
117 % 10 = 7
So 55245-43-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14ClN/c1-2-7-12-8-9-3-5-10(11)6-4-9/h3-6,12H,2,7-8H2,1H3
55245-43-7Relevant articles and documents
Synthesis and biological activity of some novel substituted quinazoline derivatives
Srivastav, Maneesh Kumar,Rajeeva,Salahuddin, Md.,Srinivasulu,Shanta Kumar
, p. 115 - 118 (2019/01/21)
A new series of 4-N-(substituted benzyl)-2-phenyl-N-propylquinazolines were synthesized. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. All the synthesized compounds were screened for their analgesic and anti-inflammatory activity. Among the synthesized compounds 5c, 5h and 5o exhibited significant analgesic activity at 60 and 90 minutes reading, while compounds 5g, 5k and 5l exhibited significant anti-inflammatory activity at 3rd and 4th hr reading.
Application of alkoxy-λ6-sulfanenitriles as strong alkylating reagents
Hao, Wei,Fujii, Takayoshi,Dong, Tiaoling,Wakai, Youko,Yoshimura, Toshiaki
, p. 193 - 198 (2007/10/03)
Alkoxy-λ6-sulfanenitriles were found to be versatile alkylating reagents toward various nucleophiles bearing at least one proton such as methanol, phenol, thiophenols, carboxylic acids, ptoluenesulfonic acid, hydrochloric acid, and primary and secondary amines. Reactivity of the alkoxy group of the λ6-sulfanenitriles showed an opposite trend to the usual SN2 character, i.e. Me (la), Pr (1b), and Bu (1d) ? i-Pr (1c). In the presence of p-TsOH, alkyl tosylates were predominantly formed instead of the alkylation products of nucleophiles. In addition, even a sterically hindered substrate, neopentyloxy-λ6-sulfanenitrile, was found to undergo an SN2 reaction toward thiophenol without any rearrangement product to give neopentyl phenyl sulfide in good yield.
