55441-71-9 Usage
Description
9-Methyluric acid, also known as 1,3,7-trimethyluric acid, is a chemical compound that occurs naturally in the human body as a metabolite of caffeine. It is produced during the breakdown of caffeine in the liver by the enzyme cytochrome P450 1A2. As a minor component among caffeine metabolites, 9-methyluric acid is excreted in urine. Studies have been conducted to explore its potential as a biomarker for caffeine intake and metabolism, as well as its role in the pharmacokinetics of caffeine. Moreover, it has been recognized as a potential marker for certain metabolic disorders, although further research is required to fully comprehend its biological significance and implications.
Uses
Used in Medical Research:
9-Methyluric acid is utilized as a biomarker for caffeine intake and metabolism, helping researchers and medical professionals to understand and monitor an individual's caffeine consumption and how their body processes it.
Used in Pharmacokinetics Studies:
9-METHYLURIC ACID serves as a valuable tool in studying the pharmacokinetics of caffeine, providing insights into how caffeine is absorbed, distributed, metabolized, and excreted by the body.
Used in Metabolic Disorder Detection:
9-Methyluric acid is employed as a potential marker for identifying certain metabolic disorders, aiding in the early diagnosis and treatment of these conditions.
Used in Urine Analysis:
In clinical and research settings, 9-methyluric acid can be detected and measured in urine samples to assess an individual's caffeine metabolism and potentially indicate the presence of specific metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 55441-71-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,4 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 55441-71:
(7*5)+(6*5)+(5*4)+(4*4)+(3*1)+(2*7)+(1*1)=119
119 % 10 = 9
So 55441-71-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N4O3/c1-10-3-2(7-6(10)13)4(11)9-5(12)8-3/h1H3,(H,7,13)(H2,8,9,11,12)
55441-71-9Relevant articles and documents
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Falconer,Gulland
, p. 1369 (1939)
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Purines. XIV [1]. Synthesis and properties of 8-nitroxanthine and its N- methyl derivatives
Mosselhi,Pfleiderer
, p. 1221 - 1228 (2007/10/02)
Xanthine (1) and its N-methyl derivatives 2-16 have been nitrated to the corresponding 8-nitro derivatives 17-32 under different reaction conditions. Nitration in glacial acetic acid with nitric acid works well with the N-7 unsubstituted and some of the 9-methylxanthines, respectively, whereas the 7- methylxanthine derivatives react best with nitronium tetrafluoroborate in sulfolane or glacial acetic acid. The 8-nitro group can be displaced nucleophilically to form 8-chloro-, 33, 34, 8-ethoxy-, 35, 36, and uric acid derivatives 37-40, respectively. The newly synthesized 8-nitroxanthines have been characterized by elemental analyses, pK-determinations and uv and 1H- nmr spectra.
