558-17-8 Usage
Description
2-IODO-2-METHYLPROPANE, also known as tert-butyl iodide, is an organic compound with the chemical formula C4H9I. It is a colorless, volatile liquid that is soluble in organic solvents and has a characteristic pungent odor. 2-IODO-2-METHYLPROPANE is characterized by its reactivity and stability, making it a versatile building block in various chemical reactions.
Uses
Used in Chemical Synthesis:
2-IODO-2-METHYLPROPANE is used as a chemical reagent for organic synthesis, particularly in the production of various organic compounds and materials. Its reactivity allows it to participate in a wide range of chemical reactions, such as substitution, elimination, and rearrangement reactions, making it a valuable tool in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
2-IODO-2-METHYLPROPANE serves as a pharmaceutical intermediate, playing a crucial role in the development and production of various drugs. Its ability to form stable intermediates and participate in key reactions makes it an essential component in the synthesis of pharmaceutical compounds, contributing to the advancement of new medications and therapies.
Additionally, 2-IODO-2-METHYLPROPANE can be used in other industries, such as the agrochemical and polymer industries, where its reactivity and stability are harnessed for the production of various products and materials.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 609, 1995 DOI: 10.1016/0040-4039(94)02315-3
Purification Methods
Vacuum distillation has been used to obtain a distillate which remained colourless for several weeks at -5o. More extensive treatment has been used by Boggs, Thompson and Crain [J Phys Chem 61 625 1957] who washed with aqueous NaHSO3 solution to remove free iodine, dried this for 1hour over Na2SO3 at 0o, and purified it by four or five successive partial freezings of the liquid to obtain colourless material and was stored at -78o with Ag wool. [Beilstein 1 IV 300.]
Check Digit Verification of cas no
The CAS Registry Mumber 558-17-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,5 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 558-17:
(5*5)+(4*5)+(3*8)+(2*1)+(1*7)=78
78 % 10 = 8
So 558-17-8 is a valid CAS Registry Number.
558-17-8Relevant articles and documents
EINE EINFACHE METHODE ZUR DARSTELLUNG TERTIAERER IODIDE
Martinez, A. Garcia,Alvarez, R. Martinez,Vilar, E. Teso,Fraile, A. Garcia,Barcina, J. Osio,et al
, p. 6441 - 6442 (1987)
Hindered alkyl iodides may be prepared conveniently by treatment of the corresponding alcohols with magnesium iodide in n-pentane.
Visible-light-mediated multicomponent reaction for secondary amine synthesis
Wang, Xiaochen,Zhu, Binbing,Dong, Jianyang,Tian, Hao,Liu, Yuxiu,Song, Hongjian,Wang, Qingmin
supporting information, p. 5028 - 5031 (2021/05/28)
The widespread presence of secondary amines in agrochemicals, pharmaceuticals, natural products, and small-molecule biological probes has inspired efforts to streamline the synthesis of molecules with this functional group. Herein, we report an operationally simple, mild protocol for the synthesis of secondary amines by three-component alkylation reactions of imines (generated in situ by condensation of benzaldehydes and anilines) with unactivated alkyl iodides catalyzed by inexpensive and readily available Mn2(CO)10. This protocol, which is compatible with a wide array of sensitive functional groups and does not require a large excess of the alkylating reagent, is a versatile, flexible tool for the synthesis of secondary amines.
A mild and highly chemoselective iodination of alcohol using polymer supported DMAP
Das, Diparjun,H Anal, Jasha Momo,Rokhum, Lalthazuala
, p. 1695 - 1701 (2017/03/08)
The synthesis of organic compounds using polymer supported catalysts and reagents, where the required product is always in solution, has been of great interest in recent years, both in industries and academia especially in pharmaceutical research. Here, a simple and efficient method for conversion of alcohols into their iodides in high yield using polymer supported 4-(Dimethylamino)pyridine (DMAP) is described. Polymer supported DMAP is used in catalytic amount and is recovered and reused several times. Additionally, this method is highly chemoselective. [Figure not available: see fulltext.]