55883-45-9

Basic information

• Product Name: Benzene, 1-bromo-4-(iodomethyl)-
• Synonyms: 4-Brom-benzyljodid;4-bromobenzyl iodide;1-bromo-4-iodomethylbenzene;p-bromobenzyl iodide
• CAS NO: 55883-45-9
• Molecular Formula: C7H6BrI
• Molecular Weight: 296.933
• Mol File: 55883-45-9.mol
• Article Data: 28

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 282.5±23.0 °C(Predicted)
• Density: 2.109±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-bromo-4-(iodomethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(iodomethyl)-(55883-45-9)
• EPA Substance Registry System: Benzene, 1-bromo-4-(iodomethyl)-(55883-45-9)

Safety Data

• Hazardous Substances Data: 55883-45-9(Hazardous Substances Data)

Upstream product

• 124129-81-3 diphosphoric acid tetrakis-(4-bromo-benzyl ester) 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1122-91-4 4-bromo-benzaldehyde 
• 130534-91-7 1-bromo-4-[(methoxymethyloxy)methyl]benzene 
• 216443-67-3 4-bromo-1-[(ethoxymethoxy)methyl]benzene 
• 106-38-7 para-bromotoluene 
• 910859-89-1 4-bromobenzyl diethyl phosphate 
• 873-75-6 4-bromobenzenemethanol 
• 86605-93-8 (4-bromobenzyloxy)trimethylsilane 
• 37853-54-6 phosphoric acid tris-(4-bromo-benzyl ester) 

Downstream Products

• 118643-62-2 (4-Bromo-benzyl)-phenyl-phosphinic acid (2S,3R)-4-iodo-2,3-dimethoxy-butyl ester 
• 142590-09-8 5-Bromo-3-(4-bromo-benzyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 
• 118150-25-7 2-(4-Bromo-benzyl)-thiophene 
• 132833-51-3 4-[(4-bromophenyl)methyl]morpholine 
• 1266681-01-9 (3S,5aR,6aS,7aS)-3-(4-bromobenzyl)-5,5a,6,6a,7,7a-hexahydro-3,6,6,7a-tetramethylbicyclo[4.1.0]hept-1⁽⁶⁾eno[3,4-b][1,4]oxazin-2(3H)-one 
• 1360871-81-3 C₂₅H₂₆BrN₂⁽¹⁺⁾*I^(1-) 
• 19829-56-2 4,4'-dibromobibenzyl 
• 20600-22-0 1-bromo-4-(phenoxymethyl)benzene 
• 1134958-19-2 4Br-C₆H₄CH₂Ph₃P(+)*Br(-) 

Relevant articles and documents

Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene

Owing to the high interest in the OCF3 group for pharmaceutical and agrochemical applications, trifluoromethoxylation received great attention in the last years with several new methods for this approach towards OCF3-comprising compounds. Yet, it most often requires the beforehand preparation of specific F3CO? transfer reagents, which can be toxic, expensive, unstable, and/or generate undesired side-products upon consumption. To circumvent this, the in-situ generation of gaseous fluorophosgene from triphosgene, its conversion by fluoride into the OCF3 anion, and the direct use of the latter in nucleophilic substitutions is an appealing strategy, which, although recently approached, has not been fully exploited. We disclose herein our efforts towards this aim.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof, which comprises the following steps: in a protective atmosphere, carrying out heating reaction on aryl aldehyde and iodine elementary substance in the presence of a solvent and phosphorous acid to obtain benzyl iodide and derivatives thereof. According to the method, cheap and green solid phosphorous acid is selected as a reduction reagent for reaction, elemental iodine is selected as an iodine source, the benzyl iodide and the derivatives thereof are efficiently prepared from the aryl aldehyde compounds which are simple and easy to obtain by a one-pot one-step method under mild conditions, and the method has the advantages of simplicity in operation, cheap and easily available reagents, environmental friendliness and the like; and the use of expensive silicon-hydrogen compounds and transition metal catalysts is avoided, and the yield can reach 94% at most, so that the method is beneficial to industrial production.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof. The preparation method comprises the following steps: under the reduction action of sodium borohydride, a benzylalcohol compound shown as a formula I reacts with elemental iodine to obtain benzyl iodide shown as a formula II and derivatives thereof; in the formula I and the formula II, R represents one or moresubstituents on a benzene ring and is selected from at least one of aryl, substituted or unsubstituted alkyl, halogen and nitro. The preparation method of benzyl iodide and derivatives thereof is scientific and reasonable, sodium borohydride which is mild in reactivity, low in price and easily available is used as a reducing agent, and elemental iodine is convenient and easily available; in addition, the preparation method has the characteristics of simplicity and convenience in operation, high synthesis yield, easiness in product purification, environmental friendliness and the like.