55968-16-6

Basic information

• Product Name: 2-THIOPHEN-2-YL-INDOLE
• Synonyms: 2-THIOPHEN-2-YL-INDOLE;2-(2-THIENYL)-1H-INDOLE;2-(Thiophen-2-yl)-1H-indole
• CAS NO: 55968-16-6
• Molecular Formula: C₁₂H₉NS
• Molecular Weight: 199.27
• Mol File: 55968-16-6.mol
• Article Data: 50

Chemical Properties

• Melting Point: 160-161 °C
• Boiling Point: 393.8 °C at 760 mmHg
• Flash Point: 190.3 °C
• Appearance: /
• Density: 1.272 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 16.77±0.30(Predicted)
• CAS DataBase Reference: 2-THIOPHEN-2-YL-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHEN-2-YL-INDOLE(55968-16-6)
• EPA Substance Registry System: 2-THIOPHEN-2-YL-INDOLE(55968-16-6)

Safety Data

• Hazardous Substances Data: 55968-16-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 2581, 1989 DOI: 10.1016/S0040-4039(01)80456-1

Upstream product

• 88-15-3 2-Acetylthiophene 
• 615-43-0 2-iodophenylamine 
• 10531-41-6 2-Bromoacetylthiophene 
• 62-53-3 aniline 
• 1003-09-4 2-bromothiophene 
• 55968-17-7 1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine 
• 3437-95-4 2-Iodothiophene 
• 120-72-9 indole 
• 52260-00-1 2-thiophene sulfonyl hydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 243844-36-2 tert-butyl (2-(chloromethyl)phenyl)-carbamate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 118-92-3 anthranilic acid 
• 164226-32-8 2-(tert-butyloxycarbonyl)aminobenzyl alcohol 

Downstream Products

• 1262895-70-4 3-(2-cyclopropyl-4-phenylbut-3-yn-2-yl)-2-(thiophen-2-yl)-1H-indole 
• 1337932-63-4 [2-(thiophen-2-yl)-1H-indol-3-yl]-(3,4,5-trimethoxyphenyl)methanone 
• 1337932-64-5 2-(thiophen-2-yl)-3-(3,4,5-trimethoxybenzyl)-1H-indole 
• 1314802-67-9 2-(thiophen-2-yl)-3-[(3',4',5'-trimethoxyphenyl)thio]-1H-indole 
• 1426243-76-6 N-((4-bromophenyl)(2-(thiophen-2-yl)-1H-indol-3-yl)methyl)toluenesulfonamide 
• 1426243-78-8 N-((2-(thiophen-2-yl)-1H-indol-3-yl)(m-tolyl)methyl)toluenesulfonamide 
• 33405-06-0 N-(2-carboxyphenyl)thiophene-2-carboxamide 
• 42239-63-4 2-aminophenyl-(thien-2-yl)methanone 

Relevant articles and documents

Spectroscopy and photophysics of bifunctional proton donor-acceptor indole derivatives

We report spectroscopic and photophysical studies of a series of selected indole derivatives in solutions and under supersonic jet isolation conditions. All the compounds can assume two rotameric forms, syn and anti. The bifunctional molecules containing

Acid-catalyzed cleavage of C-C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis

Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps: (i) SN2′ substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon-carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.

Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics

Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use ofnBu4NBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.