56047-47-3Relevant articles and documents
Single-step enzymatic conversion of peptide amides to esters
Meos, Helle,Haga, Mati,Tougu, Vello
, p. 2343 - 2346 (1995)
It is shown that the C-terminal amide groups in N-protected peptides could be efficiently replaced by ester groups via kinetically-controlled papain-catalyzed acyl transfer reactions in aqueous methanol. The specificity of papain was substantially shifted towards the cleavage of C-terminal amide bond in dipeptide substrates by methanol, thus suppressing undesired peptide bond cleavage during esterification.
N-TERMINAL SUBSTITUENT AND SIDE-CHAIN INFLUENCES ON THE CHEMICAL SHIFTS OF PROTONS IN MODEL DIPEPTIDE SYSTEMS
Davies, John S.,Hakeem, Essam
, p. 1387 - 1392 (2007/10/02)
(1)H Chemical shift values of ester methyls in model dipeptide esters have been shown to be sensitive to (a) the nature and configuration of the constituent amino acids and (b) the spatial distance between the N-terminal aryl group and the ester protons.C