56083-03-5

Basic information

• Product Name: IsobavachroMene
• Synonyms: IsobavachroMene;(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-2-propen-1-one;4-Hydroxylonchocarpin
• CAS NO: 56083-03-5
• Molecular Formula: C₂₀H₁₈O₄
• Molecular Weight: 322.35452
• Mol File: 56083-03-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 203-204℃
• Boiling Point: 535.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• PKA: 7.25±0.40(Predicted)
• CAS DataBase Reference: IsobavachroMene(CAS DataBase Reference)
• NIST Chemistry Reference: IsobavachroMene(56083-03-5)
• EPA Substance Registry System: IsobavachroMene(56083-03-5)

Safety Data

• Hazardous Substances Data: 56083-03-5(Hazardous Substances Data)

Usage

General Description

IsobavachroMene is a natural chemical compound found in plants such as Psoralea corylifolia and Angelica dahurica. It belongs to the group of compounds known as coumarins, which have been studied for their potential therapeutic effects. IsobavachroMene has been investigated for its anti-inflammatory, anti-cancer, and antioxidant properties. It has also been shown to have potential in the treatment of various health conditions such as skin disorders, cardiovascular diseases, and neurodegenerative disorders. IsobavachroMene is being researched for its potential as a natural alternative for treating various diseases and may have potential in the development of new pharmaceutical drugs.

Upstream product

• 19825-40-2 2,4-Dihydroxy-3-C-prenylacetophenone 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 24672-84-2 6-acetyl-5-hydroxy-2,2-dimethylchromene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 525-25-7 β-tubaic acid 
• 885118-28-5 5-hydroxy-2,2-dimethyl-2H-chromene-6-carboxylic acid ethyl ester 

Downstream Products

• 1615245-38-9 (E)-3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one 
• 1615245-39-0 (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1615245-40-3 (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1615245-41-4 (E)-1-(5-(2-(diethylamino) ethoxy)-2, 2-dimethyl-2H-chromen-6-yl)-3-(4-(2-(diethylamino)ethoxy) phenyl)prop-2-en-1-one 
• 1615245-42-5 (E)-1-(2,2-dimethyl-5-(2-(pyrrolidin-1-yl)ethoxy)-2H-chromen-6-yl)-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)prop-2-en-1-one 
• 1416512-06-5 1-[2,2-dimethyl-5-(2-piperidin-1-yl-ethoxy)-2H-chromen-6-yl]-3-[4-(2-piperidin-1-ylethoxy)-phenyl]-prop-2-en-1-one 
• 78316-30-0 4'-hydroxy-2,2-dimethylpyrano<5,6:8,7>flavanone 

Relevant articles and documents

Synthesis and biological evaluation of pyranoisoflavone derivatives as anti-inflammatory agents

In this paper, barbigerone (1a) and its twenty-seven related structural analogues were synthesized via complementary synthetic routes and their anti-inflammatory effects on the expression of TNF-α in LPS-stimulated splenocytes were evaluated. Among these compounds, 1a, 1d, 1f and 1g were found to remarkably inhibit TNF-α production. Furthermore, 1g showed the most potent and dose-dependent manner inhibitory effect on TNF-α release, with better IC50 value (3.58 μM) than barbigerone (8.46 μM). Oral administration of 1g at 20 mg/kg/day for two weeks obviously demonstrated protective effect in adjuvant-induced arthritis models as evaluated by clinical score of paws, and histological examination of joint tissues from rats. Mechanism studies on mRNA and protein level suggested that 1g inhibited the TNF-α production via depressing TNF-α converting enzyme (TACE) mRNA expression. In conclusion, these data show 1g with potential therapeutic effects as an anti-inflammatory agent.

A new route to the synthesis of pyranoflavone and pyranochalcone natural products and their derivatives

The total synthesis of biologically active pyranoflavone natural products 1 and 2 was carried out starting from 2H-pyran. The synthesis of pyranochalcone natural products, lonchocarpin (9) and 4-hydroxylonchocarpin (10), and their derivatives 30-32 is des

Selenium-based solid-phase synthesis of benzopyrans I: Applications to combinatorial synthesis of natural products

-