56146-83-9

Basic information

• Product Name: METHYL (CHLOROSULFONYL)ACETATE
• Synonyms: METHYL (CHLOROSULFONYL)ACETATE;Methyl 2-(Chlorosulfonyl)acetate;Acetic acid, (chlorosulfonyl)-, Methyl ester;(Methoxycarbonyl)methanesulfonyl chloride;2-Methoxy-2-oxoethanesulfonyl chloride;Chlorosulfonylacetic acid methyl ester;2-(chlorosulfonyl)Acetic acid methyl ester
• CAS NO: 56146-83-9
• Molecular Formula: C₃H₅ClO₄S
• Molecular Weight: 172.59
• Mol File: 56146-83-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 115-116℃ (15 Torr)
• Flash Point: 91.928 °C
• Appearance: /
• Density: 1.515 g/cm³
• Vapor Pressure: 0.074mmHg at 25°C
• Refractive Index: 1.466 (20℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: METHYL (CHLOROSULFONYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (CHLOROSULFONYL)ACETATE(56146-83-9)
• EPA Substance Registry System: METHYL (CHLOROSULFONYL)ACETATE(56146-83-9)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 56146-83-9(Hazardous Substances Data)

Usage

General Description

Methyl (chlorosulfonyl)acetate is a chemical compound with the molecular formula C3H5ClO4S. It is a highly reactive and versatile compound that is used in various chemical reactions and organic synthesis processes. Methyl (chlorosulfonyl)acetate is known for its ability to act as a chlorinating, sulfonating, and esterifying reagent. It is commonly used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is also used as a building block in the synthesis of various organic compounds and as a reagent in the preparation of specialty polymers. Due to its reactivity and versatile nature, it is important to handle methyl (chlorosulfonyl)acetate with caution and using appropriate safety measures.

InChI:InChI=1/C3H5ClO4S/c1-8-3(5)2-9(4,6)7/h2H2,1H3

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 96-32-2 bromoacetic acid methyl ester 
• 29508-16-5 sodium 2-methoxy-2-oxoethane-1-sulfonate 
• 67-56-1 methanol 
• 4025-77-8 chlorosulfonylacetyl chloride 

Downstream Products

• 126178-19-6 2-(4-Methoxy-phenyl)-1,1-dioxo-3-phenyl-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 117765-68-1 (4-Butoxy-phenylsulfamoyl)-acetic acid methyl ester 
• 126178-20-9 2-Benzyl-3-(4-nitro-phenyl)-1,1-dioxo-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-24-3 3-Methyl-1,1-dioxo-2-(2-phenylselanyl-ethyl)-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-18-5 1,1-Dioxo-3-phenyl-2-(2-phenylselanyl-ethyl)-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-27-6 3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,1-dioxo-2-(2-phenylselanyl-ethyl)-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-26-5 3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,1-dioxo-2-(2-phenylselanyl-ethyl)-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-25-4 2-Benzyl-3-ethyl-1,1-dioxo-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 126178-17-4 2-(2,4-Dimethoxy-benzyl)-1,1-dioxo-3-phenyl-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 82484-07-9 (6-Phenoxy-indan-5-ylsulfamoyl)-acetic acid methyl ester 
• 119481-37-7 <<<3-(2-quinolinylmethoxy)phenyl>amino>sulfonyl>acetic acid methyl ester 
• 41505-91-3 methyl 2-(fluorosulfonyl)acetate 
• 117765-69-2 (2-Nitro-phenylsulfamoyl)-acetic acid methyl ester 
• 126178-16-3 2-Benzyl-1,1-dioxo-3-phenyl-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 

Relevant articles and documents

Clickable transformation of nitriles (RCN) to oxazolyl sulfonyl fluoride warheads

The protocol for simple, efficient, and mild synthesis of oxazolyl sulfonyl fluorides was developed through Rh2(OAc)4-catalyzed annulation of methyl-2-diazo-2-(fluorosulfonyl)acetate (MDF) or its ethyl ester derivative with nitriles. This practical method provides a general and direct route to a unique class of highly functionalized oxazolyl-decorated sulfonyl fluoride warheads with great potential in medicinal chemistry, chemical biology, and drug discovery.

Iridinesulfonamide compound and use method thereof

An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation-induced cancers.

Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury

A novel class of (E)-3,4-dihydroxy styryl sulfonamides and their 3,4-diacetylated derivatives as caffeic acid phenethyl ester (CAPE) analogs was designed and prepared for improving stability and solubility of the lead compound. Their neuroprotective properties were assessed by several models. The results showed that target compounds displayed positive free radical quenching abilities, superior to that of CAPE. Compounds 6j-k and 7j-k demonstrated remarkable protection effects against damage induced by hydrogen peroxide which were apparently stronger than that of CAPE. Most of target compounds could inhibit nitric oxide production. Additionally, target compounds showed high blood-brain barrier permeability.