56353-00-5

Basic information

• Product Name: 2-phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole
• Synonyms: 2-phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole
• CAS NO: 56353-00-5
• Molecular Formula: C₁₃H₉N₃O
• Molecular Weight: 223.23006
• Mol File: 56353-00-5.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole(56353-00-5)
• EPA Substance Registry System: 2-phenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole(56353-00-5)

Safety Data

• Hazardous Substances Data: 56353-00-5(Hazardous Substances Data)

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 1570-45-2 isonicotinic acid ethylester 
• 108-89-4 picoline 
• 613-94-5 benzoic acid hydrazide 
• 54-85-3 isoniazid 
• 611-73-4 Benzoylformic acid 
• 209797-66-0 Formic acid [1-ethoxy-1-phenyl-meth-(E)-ylidene]-hydrazide 
• 1507-93-3 C₁₃H₁₁N₃O 
• 2032-36-2 Thiobenzmorpholid 
• 15563-40-3 N-thiobenzoylpiperidine 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 1663-61-2 triethoxymethylbenzene 
• 14389-12-9 5-(4-pyridyl)tetrazole 

Downstream Products

• 943860-98-8 2-(4-methoxyphenyl)-7-(5-phenyl-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 943860-97-7 2-(4-methylphenyl)-7-(5-phenyl-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 943860-96-6 2-phenyl-7-(5-phenyl-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 

Relevant articles and documents

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides

Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-l