56472-04-9

Basic information

• Product Name: 5-nitroso-2-phenylpyrimidine-4,6-diamine
• CAS NO: 56472-04-9
• Molecular Formula: C₁₀H₉N₅O
• Molecular Weight: 215.2114
• Mol File: 56472-04-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 346.7°C at 760 mmHg
• Flash Point: 163.5°C
• Density: 1.52g/cm³
• Vapor Pressure: 5.64E-05mmHg at 25°C
• Refractive Index: 1.744
• CAS DataBase Reference: 5-nitroso-2-phenylpyrimidine-4,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitroso-2-phenylpyrimidine-4,6-diamine(56472-04-9)
• EPA Substance Registry System: 5-nitroso-2-phenylpyrimidine-4,6-diamine(56472-04-9)

Safety Data

• Hazardous Substances Data: 56472-04-9(Hazardous Substances Data)

Usage

Description

5-nitroso-2-phenylpyrimidine-4,6-diamine is a pyrimidine derivative that is a nitrosamine compound, characterized by the presence of a nitroso group attached to a secondary amine group. It has potential applications in medicinal chemistry, particularly as an anticancer agent.

Uses

Used in Medicinal Chemistry:
5-nitroso-2-phenylpyrimidine-4,6-diamine is used as a potential anticancer agent due to its chemical properties and structure. It is being studied for its potential to target and treat cancer cells.
Used in Research:
5-nitroso-2-phenylpyrimidine-4,6-diamine is used in research to understand its role as a mutagen and carcinogen, as nitrosamines have been a topic of concern due to their presence in certain foods and consumer products. Further research is needed to fully understand its properties, potential uses, and any associated risks and hazards.

Upstream product

• 109-06-8 α-picoline 
• 7152-36-5 isonitrosomalononitrile benzamidine salt 
• 104-90-5 5-ethyl-2-methyl-pyridine 

Downstream Products

• 29984-62-1 4-amino-2-phenyl-7(8H)-pteridinone 
• 29984-62-1 4-amino-2-phenyl-pteridine-7-one 
• 30724-65-3 5-phenyl-6H-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-one 
• 59341-33-2 5-phenyl-4⁽⁶⁾,7-dihydro-[1,2,5]oxadiazolo[3,4-d]pyrimidine 
• 59341-32-1 5-phenyl-6H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-7-thione 
• 30787-98-5 N-(5-phenyl-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-yl)-benzamide 
• 23691-97-6 N-(5-phenyl-6,7-dihydro-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-yl)-acetamide 
• 30720-60-6 N-(5-phenyl-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-yl)-acetamide 
• 59341-30-9 N-(5-phenyl-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-yl)-toluene-4-sulfonamide 
• 59341-29-6 5-phenyl-7-pyrrolidin-1-yl-[1,2,5]oxadiazolo[3,4-d]pyrimidine 
• 59341-31-0 7-ethylsulfanyl-5-phenyl-[1,2,5]oxadiazolo[3,4-d]pyrimidine 
• 10570-18-0 4-amino-7-oxo-2-phenyl-7,8-dihydro-pteridine-6-carboxylic acid 2-morpholin-4-yl-ethylamide 
• 30720-36-6 5-phenyl-[1,2,5]oxadiazolo[3,4-d]pyrimidin-7-ylamine 
• 15048-57-4 4-(4,7-diamino-2-phenyl-pteridine-6-carbonyl)-thiomorpholine 

Relevant articles and documents

Nucleosides part LXVI I[1]: Synthesis of 4-amino-7(8H) pteridinone-N8-nucleosides-structural analogs of adenosine

Various 4-amino-7(8H)pteridones (6, 12, 14, 15, 20, 22) have been glycosylated with 1-chloro-2'-deoxy-D-ribofuranose derivatives (25, 26) applying the new DBU-salt method to form the N8-2'-deoxy-D-ribofuranosides (27-36) which can be regarded as 2'-deoxyadenosine analogs. Analogously reacted the 2-N,N-dimethyl-amino-methyleneimino-7(8H)pteridones (43-48) to give preferentially the corresponding N8-ss-D-anomers (49-55). Ribosylation with 1-bromo-2,3,5-tri-O-benzoyl-a-D-ribofuranose (56) proceeded as well with 6, 12, 15, 45, and 46 to yield to N8-ss-D-ribofuranosides 57-61. Sugar deprotection led to the free N8-2'-deoxy-ss-D-ribofuranosides 37-42 and N8-ss-D-ribofurano-sides 62-65, respectively. Glycosylations via the silyl-method under Vorbruggen conditions led with 6, 12 and 15 to the same results, however, 4-amino-6-phenyl-7(8H)pteridone (14) reacted differently forming the N1-ss-D-ribofuranosides (71, 79) and the N1-2'-deoxy - and ss-D-ribofuranosides 73, 74, 77, 78. The assignments of the structures have been achieved by 1H-NMR- and UV-spectra. C,H,N-elemental analyses account for the composition.