565176-85-4

Basic information

• Product Name: 2-Oxazolidinone, 5-[[bis(phenylmethyl)amino]methyl]-3-[3-fluoro-4-(4-morpholinyl)phenyl]-, (5S)-
• CAS NO: 565176-85-4
• Molecular Formula: C28H30FN3O3
• Molecular Weight: 475.563
• Mol File: 565176-85-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 5-[[bis(phenylmethyl)amino]methyl]-3-[3-fluoro-4-(4-morpholinyl)phenyl]-, (5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 5-[[bis(phenylmethyl)amino]methyl]-3-[3-fluoro-4-(4-morpholinyl)phenyl]-, (5S)-(565176-85-4)
• EPA Substance Registry System: 2-Oxazolidinone, 5-[[bis(phenylmethyl)amino]methyl]-3-[3-fluoro-4-(4-morpholinyl)phenyl]-, (5S)-(565176-85-4)

Safety Data

• Hazardous Substances Data: 565176-85-4(Hazardous Substances Data)

Upstream product

• 224323-51-7 3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate 
• 565176-84-3 (S)-N,N-dibenzylamino-1-(oxiran-2-ylmethyl)methylamine 
• 103-49-1 dibenzylamine 
• 1236384-02-3 (S)-3-chloro-2-hydroxypropyl dibenzylamine 
• 168828-81-7 benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate 
• 2689-39-6 3-fluoro-4-(4-morpholinyl)nitrobenzene 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 165800-03-3 linezolid 

Relevant articles and documents

METHOD FOR PREPARING LINEZOLID INTERMEDIATE

Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-(3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazoline) (I), wherein the intermediate (I) is obtained by the cyclization of 3-fluoro-4-morpholinophenyl isocyanate (II) and epoxy compound (III). This process has a short process route, low cost, easy operation, and high yield, so is suitable for a large-scale industrial production.

METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF

A method for preparing the linezolid (compound 1), which comprises the steps of: (1) carrying out the debenzyl reaction of compound 4 in solvent, to obtain the compound 5 or its acetate; (2) carrying out the acetylation reaction in the amino of the compound 5 or its acetate obtained in step (1) in solvent to obtain the compound 1. The intermediates to prepare the compound 1 and the acetate of compound 5. The present preparation method is easy to obtain the chiral materials and the chiral materials are cheap, the process and the post treatment are simple, the intermediate products and the end product are easy to be purified, the total yield is high, their purities are also high, this preparation method is easy to be used in the industry manufacture.