56805-36-8

Basic information

• Product Name: N-(tert-Butyloxycarbonyl)-N-methyl-p-toluenesulfonamide
• Synonyms: N-(tert-Butyloxycarbonyl)-N-methyl-p-toluenesulfonamide;N-Methyl-N-tosylcarbamic acid tert-butyl ester
• CAS NO: 56805-36-8
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.36
• Mol File: 56805-36-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 375.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.185±0.06 g/cm3(Predicted)
• PKA: -13.23±0.70(Predicted)
• CAS DataBase Reference: N-(tert-Butyloxycarbonyl)-N-methyl-p-toluenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-Butyloxycarbonyl)-N-methyl-p-toluenesulfonamide(56805-36-8)
• EPA Substance Registry System: N-(tert-Butyloxycarbonyl)-N-methyl-p-toluenesulfonamide(56805-36-8)

Safety Data

• Hazardous Substances Data: 56805-36-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 80-48-8 methyl p-toluene sulfonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 640-61-9 N-methyl-p-toluenesulfonylamide 

Downstream Products

• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 640-61-9 N-methyl-p-toluenesulfonylamide 

Relevant articles and documents

Efficient, scalable and economical preparation of tris(deuterium)- and 13C-labelled N-methyl-N-nitroso-p-toluenesulfonamide (Diazald) and their conversion to labelled diazomethane

A method for the preparation of multi-gramme quantities of N-methyl-d3-N-nitroso-p-toluenesulfonamide (Diazald-d3) and N-methyl-13C-N-nitroso-p-toluenesulfonamide (Diazald-13C) and their conversion to diazomethane-d2 and diazomethane-13C, respectively, is presented. This approach uses robust and reliable chemistry, and critically, employs readily commercially available and inexpensivemethanol as the label source. Several reactions of labelled diazomethane are also reported, including alkene cyclopropanation, phenolmethylation and α-diazoketone formation, as well as deuteriumscrambling in the preparation of diazomethane-d2 and subsequent methyl esterification of benzoic acid.

NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF

A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.