5696-15-1 Usage
Description
ALPHA-[1-(T-BUTYLAMINO)ETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE is a chemical compound with a complex structure, characterized by its hydrochloride salt form. It is derived from benzyl alcohol and features a T-butylaminoethyl group attached to the alpha position, along with two methoxy groups at the 2,5 positions. ALPHA-[1-(T-BUTYLAMINO)ETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE has potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
ALPHA-[1-(T-BUTYLAMINO)ETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE is used as a beta-2 selective beta blocker for the treatment of various conditions. As a β2-adrenergic receptor (AR) antagonist, it helps in managing symptoms related to excessive stimulation of the adrenergic receptors, such as hypertension, asthma, and other respiratory disorders.
Used in Cardiology:
In the field of cardiology, ALPHA-[1-(T-BUTYLAMINO)ETHYL]-2,5-DIMETHOXYBENZYL ALCOHOL HYDROCHLORIDE is used as an antiarrhythmic agent. It helps in regulating the heart's rhythm and preventing irregular heartbeats, which can be crucial in managing and treating various cardiac conditions.
Originator
Butoxamine,SigmaAldrich
Manufacturing Process
548.0 g (2 mol) of 2,5-dimethoxy-α-bromopropiophenone was dissolved in
500 ml of acetanitrile and 365.0 g (5 mol) of t-butylamine was added. The
solution was allowed to stand at room temperature for 64 h and was then
diluted with 2 L of anhydrous ether. The precipitated t-butylamine
hydrobromide was filtered off and washed with ether. The filtrate and
washings were concentrated in vacuo using a water-bath kept at 40°C. When
most of the solvent had been removed, the residual material was dissolve in
cold methanol and acidified with hydrochloric acid. The solution was then
taken down to dryness in vacuo on the steam bath and the 1-(2,5-
dimethoxyphenyl)-2-(t-butylamino)propiophenone was obtained, melting point
175-176°C (recrystallised from an ethanol ether mixture).The bulk of the 1-(2,5-dimethoxyphenyl)-2-(t-butylamino)propiophenone was
dissolved in methanol and hydrogenated over platinum (Adams' catalyst).
After removal of the catalyst, the solvent was removed in vacuo and the
residual solid was dissolved in water and the solution was washed with ether.The aqueous layer was basified (dilute sodium hydroxide solution) and the
base was taken into ether. After drying over anhydrous potassium carbonate,
the ether was evaporated and the base was distille at 0.3 mm pressure. So
the DL-erythro 1-(2,5-dimethoxyphenyl)-2-(t-butylamino)propanol, boiling
point 127-128°C was obtained.
Therapeutic Function
Oral hypoglycemic, Antihyperlipidemic
Check Digit Verification of cas no
The CAS Registry Mumber 5696-15-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,9 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5696-15:
(6*5)+(5*6)+(4*9)+(3*6)+(2*1)+(1*5)=121
121 % 10 = 1
So 5696-15-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H