57-14-7Relevant articles and documents
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Klager et al.
, p. 119 (1960)
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POLAROGRAPHIC AND VOLTAMMETRIC DETERMINATION OF 1-(2'-NITROPHENYL)-3,3-DIMETHYLTRIAZENE
Barek, Jiri,Drevinkova, Dana,Zima, Jiri
, p. 2021 - 2038 (1993)
The polarographic behaviour of 1-(2'-nitrophenyl)-3,3-dimethyltriazene in a mixed aqueos-methanolic solvent was investigated by tast polarography, differential pulse polarography, and fast scan differential pulse voltammetry at a hanging mercury drop electrode.A mechanism is suggested for the reduction of the compound investigated.The optimum conditions were found for the determination of this analyte by tast polarography over the concentration region of 100 to 2 μmol l-1 and by differential pulse polarography or fast scan differential pulse voltammetry at a hanging mercury drop electrode over the region of 100 to 0.2 μmol l-1.Additional sensitivity increase in the last-mentioned technique was achieved by adsorptive accumulation of analyte on the ahnging mercury drop surfase, owing to which the concentration region was depressed to 0.1 - 0.02 μmol l-1.
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Wannagat,U.,Hoefle,F.
, p. 976 - 983 (1966)
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Preparation method of PI3K inhibitor
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Paragraph 0062; 0065-0066, (2020/08/02)
The invention provides a preparation method of a PI3K inhibitor. The PI3K inhibitor is (S)-2-[1-(9H-purine-6-ylamino) ethyl]-3-(dimethylamino)-5-fluoroquinazoline-4 (3H)-ketone, and the structural formula of the PI3K inhibitor is shown in the specification. The method comprises three steps of reactions. The method has the advantages of simple reaction steps, mild reaction conditions, indiscriminate application of the solvent, economy and environmental protection. The PI3K inhibitor is subjected to optical purification and salifying crystallization refining through organic acid resolution and has simplicity in operation, improved yield, low cost and more stable batch-to-batch quality in comparison with present silica gel column chromatography and preparation separation and is suitable for industrial production.
Interaction between substituted chloramines and liquid ammonia using the indirect Raschig process
Stephan, Juliette,Berthet, Jacques,Goutelle, Veronique,Pasquet, Veronique,Delalu, Henri
, p. 808 - 812 (2007/10/03)
In this paper, different hydrazines are synthesised by the indirect Raschig process. This consists of introducing a substituted chloramine (R 1R2NCl) into liquid ammonia under pressure to obtain the corresponding hydrazine (R1R2NNH2). The experimental results, in disagreement with those reported in the literature, lead us to propose a new mechanistic scheme involving a chlorine transfer reaction. Thus, the formation of chloramine (NH2Cl) and the amine (R1R2NH) occurs first. Chloramine reacts immediately with the substituted amine, in agreement with the direct Raschig process, to produce the hydrazine. Under these conditions, the nature of the hydrazine is kinetically controlled by the excess amine. It is then possible to synthesise different hydrazines from the same substituted chloramine. This mechanism is validated by the following syntheses: unsymmetric dimethylhydrazine (UDMH), N-aminopiperidine (NAPP) and N-amino 3-azabicyclo[3.3.0]octane (NAZA).