57078-37-2

Basic information

• Product Name: N-hydroxy-5-norbornene-2,3-dicarboximide ester of N-benzyloxycarbonyl-DL-2-hydroxy-4-aminobutanoic acid
• CAS NO: 57078-37-2
• Molecular Weight: 414.415
• Mol File: 57078-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-hydroxy-5-norbornene-2,3-dicarboximide ester of N-benzyloxycarbonyl-DL-2-hydroxy-4-aminobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxy-5-norbornene-2,3-dicarboximide ester of N-benzyloxycarbonyl-DL-2-hydroxy-4-aminobutanoic acid(57078-37-2)
• EPA Substance Registry System: N-hydroxy-5-norbornene-2,3-dicarboximide ester of N-benzyloxycarbonyl-DL-2-hydroxy-4-aminobutanoic acid(57078-37-2)

Safety Data

• Hazardous Substances Data: 57078-37-2(Hazardous Substances Data)

Upstream product

• 21715-90-2 N-hydroxy-5-norbornene-2,3-dicarboximide 
• 54755-69-0 L-(-)-4-benzyloxycarbonylamino-2-hydroxybutyric acid 

Downstream Products

• 66962-71-8 4-N-(D,L-2-hydroxy-4-aminobutanoyl)glycyl-tetra-N-benzyloxycarbonylfortimicin B 

Relevant articles and documents

4-N-acylfortimicins B and the preparation of fortimicin A from fortimicin B.

Selective 4-N-acylation of fortimicin B (2) has been accomplished by 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (4) followed by hydrogenolysis of the N-protecting benzyloxycarbonyl groups. In this manner, fortimicin B was converted into fortimicin A (1), and a series of 4-N-acylfortimicins B (3) was prepared for antibacterial assay. The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter.